Risk tables for parkinsonism and Parkinson's disease
Risk tables for parkinsonism and Parkinson's disease
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DOI：
10.1016/s0895-4356(01)00425-5
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发表时间：
2002-01-01
影响因子：
7.2
通讯作者：
Rocca, WA
中科院分区：
文献类型：
--
作者：
Elbaz, A;Bower, JH;Rocca, WA
我们将明尼苏达州奥姆斯特德县 (1976-1990) 的帕金森病和帕金森病 (PD) 的发病率应用于在明尼苏达州观察到的死亡率的假设队列，并计算了患帕金森病和帕金森病的终生风险和剩余终生风险。将这些风险与不考虑死亡竞争风险的累积发生率进行比较。从出生起患帕金森病的终生风险男性为 4.4%，女性为 3.7%（比率 = 1.2）。男性患 PD 的相应风险为 2.0%，女性为 1.3%（比率 = 1.5）。由于男性较高的发病率和较高的死亡率的相反影响，男性的终生风险仅略高于女性。终生累积发病率始终高于终生风险；这种差异在男性和老年受试者中更为明显。终生风险估计在临床实践、流行病学研究和公共卫生中很有用。 (C) 2002 Elsevier Science Inc. 保留所有权利。
We applied the incidence rates of parkinsonism and Parkinson's disease (PD) from Olmsted County, MN (1976-1990) to a hypothetical cohort undergoing the mortality rates observed in Minnesota, and computed the lifetime risk and the remaining lifetime risk of developing parkinsonism and PD. These risks were compared to cumulative incidences that do not take competing risks of death into account. The lifetime risk of developing parkinsonism from birth was 4.4% for men and 3.7% for women (ratio = 1.2). The corresponding risk of developing PD was 2.0% for men and 1.3% for women (ratio = 1.5). Because of the opposite effect of higher incidence and higher mortality rates in men, the lifetime risks were only slightly higher in men than in women. Lifetime cumulative incidences were consistently higher than lifetime risks; this difference was more pronounced in men and in older subjects. Lifetime risk estimates are useful in clinical practice, epidemiologic research, and public health. (C) 2002 Elsevier Science Inc. All rights reserved.