Lower Masticatory Performance Is a Risk for the Development of the Metabolic Syndrome: The Suita Study.
Lower Masticatory Performance Is a Risk for the Development of the Metabolic Syndrome: The Suita Study.
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DOI：
10.3389/fcvm.2021.752667
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发表时间：
2021
影响因子：
3.6
通讯作者：
Ikebe K
中科院分区：
文献类型：
--
作者：
Fushida S;Kosaka T;Nakai M;Kida M;Nokubi T;Kokubo Y;Watanabe M;Miyamoto Y;Ono T;Ikebe K
目的：咀嚼功能下降最近受到关注，作为一个危险因素，一般健康状况不佳。本纵向分析进行了澄清咀嚼性能下降和代谢综合征（MetS）在日本的一般城市队列的发展之间的关系。研究方法：我们调查了599名参与者（254名男性，345名女性;基线平均年龄为65.8 ± 7.8岁），他们在Suita研究中接受了身体健康检查。我们使用测试软糖评估了基线时的咀嚼性能，并将参与者分为两组：“较低组”，包括基线时咀嚼性能较低25%的参与者;和“正常组”，包括所有其他人。我们使用考克斯比例风险回归分析来估计低血糖组的风险比（HR），以在随访时制定MetS和MetS的组成部分，调整年龄、吸烟状况和牙周状况。结果如下：在考克斯比例风险回归分析中，男性中低血糖组发生MetS的多变量校正风险比为2.24（95%置信区间，1.12-4.50）。在男性中，发生高血压的多变量校正风险比为3.12（1.42-6.87），高甘油三酯为2.82（1.18-6.76），高空腹血糖为2.65（1.00-7.00）。结论：较低的咀嚼性能被认为是代谢综合征以及代谢综合征组分（如高血压、高甘油三酯和高空腹血糖）在日本男性中发展的风险因素。
Objectives: Declined masticatory function has recently been receiving attention as a risk factor for poor general health. The present longitudinal analysis was conducted to clarify the relationship between decreased masticatory performance and the development of the metabolic syndrome (MetS) in a general urban cohort in Japan. Methods: We surveyed 599 participants (254 men, 345 women; mean age at baseline, 65.8 ± 7.8 years) who underwent physical health checkups in the Suita study. We evaluated masticatory performance at baseline using test gummy jelly and divided participants into two groups: a “Lower group,” comprising participants in the lower 25% of the masticatory performance at baseline; and a “Normal group,” comprising all others. We estimated hazard ratios (HRs) for the Lower group by using Cox proportional hazard regression analysis to develop the MetS and the components of the MetS at follow-up, adjusting for age, smoking status, and periodontal status. Results: On Cox proportional hazard regression analysis, the multivariable adjusted hazard ratio for the development of the MetS in the Lower group was 2.24 (95% confidence interval, 1.12–4.50) in men. The multivariable adjusted hazard ratio for the development of high blood pressure was 3.12 (1.42–6.87), for high triglycerides was 2.82 (1.18–6.76), and for high fasting plasma glucose was 2.65 (1.00–7.00) in men. Conclusions: Lower masticatory performance suggested to be a risk factor for the development of the MetS as well as MetS components such as high blood pressure, high triglycerides, and high fasting plasma glucose in Japanese men.