Loci on chromosomes 2 (NIDDM1) and 15 interact to increase susceptibility to diabetes in Mexican Americans
Loci on chromosomes 2 (NIDDM1) and 15 interact to increase susceptibility to diabetes in Mexican Americans
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DOI：
10.1038/6002
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发表时间：
1999-02-01
期刊：
影响因子：
30.8
通讯作者：
Kong, A
中科院分区：
文献类型：
--
作者：
Cox, NJ;Frigge, M;Kong, A
诸如糖尿病，心血管疾病，哮喘，高血压和精神疾病之类的复杂疾病占医疗保健费用的很大且比例不成比例的份额，但在病因学方面的特征仍然很差。这种疾病的传播很复杂，反映了多种遗传和环境因素的作用和相互作用。允许同时考虑多个区域易感性的遗传分析可能会提高映射基因的复杂疾病（1,2）的能力（1,2），但是此类分析目前是计算强度的，并且狭义地集中了。我们在这里描述了一种评估未链接区域之间统计相互作用的证据的方法，该区域允许多点等位基因共享分析在一个区域中考虑一个链接的证据，以评估基因组的其余部分的链接证据。使用这种方法，我们表明，染色体2（NIDDM1）和15（CYP19附近）上基因的相互作用为来自德克萨斯州Starr县的墨西哥裔美国人的2型糖尿病的敏感性做出了贡献。
Complex disorders such as diabetes, cardiovascular disease, asthma, hypertension and psychiatric illnesses account for a large and disproportionate share of health care costs, but remain poorly characterized with respect to aetiology. The transmission of such disorders is complex, reflecting the actions and interactions of multiple genetic and environmental factors. Genetic analyses that allow for the simultaneous consideration of susceptibility from multiple regions may improve the ability to map genes for complex disorders(1,2), but such analyses are currently computationally intensive and narrowly focused. We describe here an approach to assessing the evidence for statistical interactions between unlinked regions that allows multipoint allele-sharing analysis to take the evidence for linkage at one region into account in assessing the evidence for linkage over the rest of the genome. Using this method, we show that the interaction of genes on chromosomes 2 (NIDDM1) and 15 (near CYP19) makes a contribution to susceptibility to type 2 diabetes in Mexican Americans from Starr County, Texas.