Quadriceps intramuscular fat fraction rather than muscle size is associated with knee osteoarthritis
Quadriceps intramuscular fat fraction rather than muscle size is associated with knee osteoarthritis
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DOI：
10.1016/j.joca.2013.12.005
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发表时间：
2014-02-01
影响因子：
7
通讯作者：
Souza, R. B.
中科院分区：
文献类型：
--
作者：
Kumar, D.;Karampinos, D. C.;Souza, R. B.
目的：比较膝关节x线性骨关节炎（ROA）患者与非膝关节x线性骨关节炎（ROA）患者大腿肌肉肌内脂肪（intraMF）含量及面积；并评估股四头肌脂肪和面积与力量、功能和膝关节磁共振成像（MRI）病变的关系。方法：96例受试者(ROA: Kellgren Lawrence (KL) bbb1；n = 30，对照：KL = 0,1；n = 66)使用基于化学移位的水/脂肪MRI（脂肪部分）和膝关节（临床分级）对大腿肌肉进行3-T MRI检查。评估受试者的等长/等速股四头肌/腘绳肌力量、功能、膝关节损伤和骨关节炎结局评分（MOOS）、爬楼梯测试（SCT）和6分钟步行测试（6MWT）。在调整了年龄后，比较了对照组和ROA受试者的大腿肌内amf分数、肌肉面积和力量以及功能。使用回归和相关分析评估肌肉脂肪/面积与力量、功能、KL和病变评分之间的关系。结果：ROA组MOOS评分较低，SCT与6MWT评分差异无统计学意义。ROA组有较大的股四头肌amf内分数，但其他肌肉没有。ROA组股四头肌力量较低，但面积无差异。股四头肌amf内分数而非面积预测自我报告的残疾。衰老、IC恶化、软骨和半月板病变与股四头肌amf分数升高有关。结论：膝OA患者amf内股四头肌较高，与膝OA的症状和结构严重程度有关，而股四头肌面积与此无关。基于化学位移的水/脂肪磁共振成像的股四头肌脂肪分数可能作为膝关节OA疾病进程的结构和症状严重程度的标志。(C) 2013年国际骨关节炎学会。Elsevier Ltd.出版。版权所有。
Objectives: To compare thigh muscle intramuscular fat (intraMF) fractions and area between people with and without knee radiographic osteoarthritis (ROA); and to evaluate the relationships of quadriceps adiposity and area with strength, function and knee magnetic resonance imaging (MRI) lesions.Methods: Ninety six subjects (ROA: Kellgren Lawrence (KL) > 1; n = 30, control: KL = 0, 1; n = 66) underwent 3-T MRI of the thigh muscles using chemical shift-based water/fat MRI (fat fractions) and the knee (clinical grading). Subjects were assessed for isometric/isokinetic quadriceps/hamstrings strength, function Knee injury and Osteoarthritis Outcome Score (MOOS), stair climbing test (SCT), and 6-minute walk test (6MWT). Thigh muscle intraMF fractions, muscle area and strength, and function were compared between controls and ROA subjects, adjusting for age. Relationships between measures of muscle fat/area with strength, function, KL and lesion scores were assessed using regression and correlational analyses.Results: The ROA group had worse MOOS scores but SCT and 6MWT were not different. The ROA group had greater quadriceps intraMF fraction but not for other muscles. Quadriceps strength was lower in ROA group but the area was not different. Quadriceps intraMF fraction but not area predicted self-reported disability. Aging, worse IC, and cartilage and meniscus lesions were associated with higher quadriceps intraMF fraction.Conclusion: Quadriceps intraMF is higher in people with knee OA and is related to symptomatic and structural severity of knee OA, whereas the quadriceps area is not. Quadriceps fat fraction from chemical shift-based water/fat MR imaging may have utility as a marker of structural and symptomatic severity of knee OA disease process. (C) 2013 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.