EFFECT OF EPIDERMAL GROWTH-FACTOR ON LUNG MATURATION IN FETAL RABBITS
EFFECT OF EPIDERMAL GROWTH-FACTOR ON LUNG MATURATION IN FETAL RABBITS
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DOI：
10.1203/00006450-197902000-00004
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发表时间：
1979-01-01
影响因子：
3.6
通讯作者：
STAHLMAN, MT
中科院分区：
文献类型：
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作者：
CATTERTON, WZ;ESCOBEDO, MB;STAHLMAN, MT
将表皮生长因子(EGF)注射到24天的兔胚胎(5微克，肌肉注射)中。或I.P.)诱导肺的加速成熟。在第27天处死时，随着II型细胞的出现接近足月兔的水平，与放气相关的扩张性和稳定性更强。在这组动物中，EGF治疗对体重或肺重量没有明显影响。注射生理盐水的对照组胎儿没有受到明显影响。EGF能明显促进胎兔肺上皮细胞的生长和分化。它可能是[人类]肺成熟过程中的一种重要激素，能够保护早产胎儿免受肺透明膜病的侵袭。
Injection of epidermal growth factor (EGF) into 24-day rabbit fetuses (5 .mu.g, i.m. or i.p.) induced accelerated maturation of the lung. On sacrifice at day 27, there was greater distensibility and stability on deflation associated with the appearance of a complement of type II cells approaching that of the rabbit at term. EGF treatment had no demonstrable effect on body weight or lung weight in this group of animals. Saline-injected control fetuses were not affected significantly. EGF apparently is capable of promoting epithelial cell growth and of differentiation in the fetal rabbit lung. It may be an important hormone in the maturation of the [human] lung and capable of protecting the prematurely delivered fetus against the development of hyaline membrane disease.