Hyperthermia (42°C) as an Adjuvant to Radiotherapy and Chemotherapy in the Treatment of the Allogeneic VX2 Carcinoma in the Rabbit
Hyperthermia (42°C) as an Adjuvant to Radiotherapy and Chemotherapy in the Treatment of the Allogeneic VX2 Carcinoma in the Rabbit
复制标题
热疗 (42°C) 作为放疗和化疗的辅助治疗兔同种异体 VX2 癌
作者：
D. Muckle;J. A. D1ckson;Selawry Carlson;Moore
通过肿瘤体积的减小和肿瘤细胞呼吸和糖酵解的抑制来评估，高温（肿瘤内温度42°C持续1小时）增强了放射治疗（1000 rad）对兔后肢同种异体VX 2癌的破坏作用，而化疗（甲氨蝶呤）产生了类似的放射增强作用。在双重治疗后，每种情况下的原发性肿瘤的消退与3次局部热疗后发生的消退相当，局部热疗已被证明治愈了50%的患有这种癌症的动物。联合治疗没有增加兔子的存活时间，然而，所有兔子在尸检时都有肺和淋巴结转移。结果集中注意力在原发肿瘤和其转移之间的关系。组织学图片和动物存活数据表明，治疗后肿瘤细胞死亡和坏死物质再吸收的机制可能在使宿主能够处理转移性细胞方面很重要。联合治疗后，许多代谢和有丝分裂活性的癌细胞保留在肿瘤块中，原发性肿瘤的不完全破坏可能给宿主留下了太大而无法被免疫系统破坏的肿瘤细胞负担。
As assessed by decrease in tumour volume and inhibition of tumour cell respiration and glycolysis, hyperthermia (intra-tumour temperature 42°C for one hour) potentiated the destructive effect of radiotherapy (1000 rad) on the allogeneic VX2 carcinoma in the hind limb of rabbits, and chemotherapy (methotrexate) produced a similar potentiation of irradiation. The resulting regression of the primary tumour in each case after dual therapy was comparable to that occurring after 3 applications of local hyperthermia, which has been shown to cure 50% of animals with this carcinoma. Combination therapy did not increase the survival time of the rabbits, however, all of which had lung and lymph node metastases at autopsy. The results focus attention on the relationship between a primary tumour and its metastases. The histological picture and the animal survival data suggest that the mechanism of tumour cell death and resorption of necrotic material following treatment may be important in enabling the host to deal with metastatic cells. After combination therapy, many metabolically and mitotically active cancer cells remained in the tumour mass, and the incomplete destruction of the primary tumour may have left the host with a burden of tumour cells too large to be destroyed by the immune system.