Monounsaturated and ω-3 but not ω-6 polyunsaturated fatty acids improve hepatic fibrosis in hypercholesterolemic rabbits
Monounsaturated and ω-3 but not ω-6 polyunsaturated fatty acids improve hepatic fibrosis in hypercholesterolemic rabbits
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DOI：
10.1016/j.nut.2004.06.029
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发表时间：
2005-03-01
期刊：
影响因子：
4.4
通讯作者：
Ramirez-Tortosa, MC
中科院分区：
文献类型：
--
作者：
Aguilera, CM;Ramirez-Tortosa, CL;Ramirez-Tortosa, MC
目的：虽然饱和脂肪酸，单不饱和脂肪酸（MUFAs），多不饱和脂肪酸（PUFAs），脂质，胆固醇水平和其他血脂的影响已经建立，很少有研究检查这些饮食脂质的组成和组织学损伤的器官的情况下，高胆固醇血症的影响。胆汁脂质来自肝脏，并且该器官在胆固醇稳态中是必不可少的;因此，在具有不同膳食脂质的高胆固醇血症的情况下，评价胆汁、肝脂质和肝毒性效应之间的相互关系可能是有帮助的。本研究调查是否管理的饮食不同的脂肪酸配置文件（ω-3 PUFA，ω-6 PUFA，或单不饱和脂肪酸）的影响的内容，胆固醇含量，胆囊胆汁的结石指数，和发展的肝纤维化在hypercholesterolemic rabbits.Methods：30只兔子被随机分为五组之一。对照组喂饲兔饲料80 d。其余四组接受了50天的饮食，其中含有3%的猪油和13%的胆固醇，以引起高胆固醇血症。在此期间之后，三组分别用富含omega-6 PUFA、MUFA和omega-3 PUFA的饮食喂养另外30天。肝脏，胆汁，和血浆脂质成分，脂质过氧化在肝线粒体，和组织学肝脏病变进行了analysed.Results和结论：有一个有益的影响，单不饱和脂肪酸和ω-3多不饱和脂肪酸对高胆固醇血症兔肝纤维化，因为这两种饮食脂肪导致从肝脏病变的恢复。然而，由于摄入omega-3 PUFA会引起家兔胆汁结石，因此摄入MUFA更可取。(C)2005年爱思唯尔公司All rights reserved.
Objective: Although the influence of saturated fatty acids, monounsaturated fatty acids (MUFAs), polyunsaturated fatty acids (PUFAs), lipids, cholesterol levels, and other blood lipids has been established, few studies have examined the influence of these dietary lipids on the composition and histologic damage of organs in situations of hypercholesterolemia. Biliary lipids come from the liver, and this organ is essential in cholesterol homeostasis; thus, it may be helpful to evaluate the inter-relations among biliary, hepatic lipids, and hepatotoxic effects in situations of hypercholesterolemia with different dietary lipids. This study investigated whether administration of diets differing in fatty acid profiles (omega-3 PUFA, omega-6 PUFA, or MUFA) influence the content of biliary lipids, the lithogenic index of gallbladder bile, and the development of hepatic fibrosis in hypercholesterolemic rabbits.Methods: Thirty rabbits were randomized to one of five groups. A control group received rabbit chow for 80 d. The remaining four groups received a 50-d diet that contained 3% lard and 13% cholesterol to provoke hypercholesterolemia. After this period, three groups were fed for another 30 d on a diet enriched with omega-6 PUFAs, MUFAs, and omega-3 PUFAs, respectively. Liver, bile, and plasma lipid compositions, lipid peroxidation in hepatic mitochondria, and histologic hepatic lesions were analyzed.Results and conclusions: There was a beneficial effect of MUFA and omega-3 PUFA on hepatic fibrosis in hypercholesterolemic rabbits because both dietary fats led to recovery from hepatic lesions. However, because intake of omega-3 PUFA provoked lithogenic bile in rabbits, MUFA intake would be more advisable. (C) 2005 Elsevier Inc. All rights reserved.