Metabolic and structural impairment of skeletal muscle in heart failure.

Metabolic and structural impairment of skeletal muscle in heart failure.
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DOI:
10.1007/s10741-012-9353-8
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发表时间:
2013-09
影响因子:
4.6
通讯作者:
Schulze, P. Christian
Schulze, P. Christian
中科院分区:
医学2区
文献类型:
--
作者:
Zizola, Cynthia;Schulze, P. Christian

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生理耐力运动表现主要受心脏功能的限制。在心力衰竭患者中,心脏功能和运动能力之间存在分离,表明外周器官功能异常(包括骨骼肌功能)的独特作用。心力衰竭对骨骼肌和运动能力的影响将讨论与心力衰竭患者的骨骼肌分子,结构和功能紊乱的重点。
Physiologic endurance exercise performance is primarily limited by cardiac function. In patients with heart failure, there is dissociation between cardiac performance and exercise capacity, suggesting a distinct role of abnormal peripheral organ function, including skeletal muscle function. The impact of heart failure upon skeletal muscle and exercise performance will be discussed with a focus on molecular, structural, and functional derangements in skeletal muscle of patients with heart failure.
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