MEASLES IMMUNIZATION IN CHILDREN WITH ALLERGY TO EGG
MEASLES IMMUNIZATION IN CHILDREN WITH ALLERGY TO EGG
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DOI：
10.1136/bmj.309.6949.223
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发表时间：
1994-07-23
影响因子：
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通讯作者：
KEMP, A
中科院分区：
文献类型：
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作者：
AICKIN, R;HILL, D;KEMP, A
研究鸡蛋过敏儿童单剂接种麻疹疫苗的不良反应发生情况，并确定皮内皮肤点刺试验阳性儿童单剂接种疫苗是否与不良反应相关，设计-回顾96名连续就诊的儿童接受疫苗皮内皮肤试验的免疫接种结果和前瞻性研究。儿童过敏中心。受试者-410名儿童敏感鸡蛋提到的过敏单位咨询麻疹免疫接种。主要结果的措施-性质和严重程度的反应与管理麻疹疫苗。结果-所有儿童有一个阳性结果在皮肤点刺试验与鸡蛋白色，和五个有一个阳性结果在皮肤点刺试验与疫苗。在连续96名儿童中，46名在疫苗皮内试验中呈阳性结果。在接种全剂量（0.5 ml）疫苗后，4名儿童出现了轻微的不良反应，其中没有一名儿童需要治疗。皮内疫苗皮试阳性的46名儿童中，只有1名儿童出现了与接种疫苗有关的反应。麻疹疫苗皮肤点刺试验结果呈阳性的儿童中没有一个对疫苗有反应。不需要治疗的疫苗的轻微反应率为0.98%（95%置信区间为0.27%至2.48%），需要治疗的严重反应为0%（0%至0. 9% h.Conclusion-chiidren与IgE介导的鸡蛋蛋白过敏反应，应调查和管理的从业人员在这个问题上的特殊知识。麻疹免疫接种应在任何不良反应都能得到适当处理的环境中进行。皮肤测试和麻疹疫苗和脱敏是没有必要的。
Objective-To examine the occurrence of adverse reactions to measles vaccine given as a single dose to children with egg allergy, and to determine if the administration of single dose to children with a positive result in an intradermal skin prick test with the vaccine is associated with adverse reactions, Design-Review of results of immunisation and prospective study of 96 consecutively presenting children given intradermal skin testing with the vaccine.Setting-Children's allergy centre.Subjects-410 children sensitive to egg referred to the allergy unit for advice about measles immunisation.Main outcome measures-Nature and severity of reactions associated with the administration of measles vaccine.Results-All children had a positive result in a skin prick test with egg white, and five had a positive result in a skin prick test with vaccine. Of 96 consecutive children, 46 had a positive result in an intradermal test with vaccine. After immunisation with a full dose (0.5 ml) of vaccine adverse reactions were associated with a mild reaction in four children, none of whom required treatment. Only one of the 46 children with a positive result in an intradermal vaccine skin test had a reaction associated with vaccine administration. None of the children with a positive result in a skin prick test with measles vaccine reacted to the vaccine. The rate of minor reactions to the vaccine not requiring treatment was 0.98% (95% confidence interval 0.27% to 2.48%) and serious reactions requiring treatment was 0% (0% to 0.9%).Conclusion-Chiidren with IgE mediated allergic reactions to egg protein should be investigated and managed by practitioners with special knowledge in this subject. Measles immunisation should be performed in a setting where any adverse reactions can be dealt with appropriately. Skin tests and measles vaccine and desensitisation are not necessary.