Aptamers and the RNA World, Past and Present
Aptamers and the RNA World, Past and Present
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DOI：
10.1101/cshperspect.a003582
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发表时间：
2012-03-01
影响因子：
7.2
通讯作者：
Zichi, Dom
中科院分区：
文献类型：
--
作者：
Gold, Larry;Janjic, Nebojsa;Zichi, Dom
适体和SELEX过程是二十多年前发现的。这些发现催生了一个多产的学术和商业产业。集体结果提供了对生物学的见解，过去和现在，通过体外进化探索核酸的性质及其在古代生命中的潜在作用。适体帮助引领了RNA的复兴。在这里，我们探讨了适体领域的一些演变，以及它为概念化RNA世界提供的见解，从它的诞生到我们目前在人类蛋白质组学中采用适体来发现健康和疾病的生物标志物的奋进。
Aptamers and the SELEX process were discovered over two decades ago. These discoveries have spawned a productive academic and commercial industry. The collective results provide insights into biology, past and present, through an in vitro evolutionary exploration of the nature of nucleic acids and their potential roles in ancient life. Aptamers have helped usher in an RNA renaissance. Here we explore some of the evolution of the aptamer field and the insights it has provided for conceptualizing an RNA world, from its nascence to our current endeavor employing aptamers in human proteomics to discover biomarkers of health and disease.