Estrogen and neuroinflammation
Estrogen and neuroinflammation
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DOI：
10.1016/s0090-4295(01)01124-4
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发表时间：
2001-06-01
期刊：
影响因子：
2.1
通讯作者：
Wang, ZY
中科院分区：
文献类型：
--
作者：
Bjorling, DE;Wang, ZY
女性比男性有更高的炎症性疾病的发病率，也似乎感知疼痛刺激不同。已经表明，神经炎症在病因不明的疼痛性膀胱疾病中起作用，例如间质性膀胱炎。神经生长因子（NGF）是外周组织中产生的一种神经营养因子，也可以介导疼痛和炎症。我们发现用雌激素拮抗剂ICI 182，780治疗小鼠对膀胱NGF含量没有影响，但降低了膀胱NGF信使RNA。使用免疫组织化学，我们证明了粘膜是小鼠膀胱中NCF的主要来源，并且膀胱粘膜还表达雌激素受体（ER）-α、ER-β和高亲和力NGF受体酪氨酸激酶A。雌激素还可以通过与参与神经源性炎症发病机制的其他物质和细胞（包括P物质、缓激肽和肥大细胞）相互作用来调节神经源性炎症。总的来说，这些观察结果表明，雌激素有能力影响膀胱神经源性炎症的发病和病程。(C)2001年，Elsevier Science Inc.
Women have a higher incidence of inflammatory disorders than men and also appear to perceive painful stimuli differently. It has been suggested that neuroinflammation plays a role in painful bladder disorders of uncertain etiology, such as interstitial cystitis. Nerve growth factor (NGF) is a neurotrophin produced in peripheral tissues that can also mediate pain and inflammation. We found that treatment of mice with the estrogen antagonist ICI 182,780 had no effect on bladder NGF content but decreased bladder NGF messenger RNA. Using immunohistochemistry, we demonstrated that the mucosa is the primary source of NCF in the mouse bladder, and the bladder mucosa also expresses estrogen receptor (ER)-alpha, ER-beta, and the high-affinity NGF receptor tyrosine kinase A. Estrogen may also modulate neurogenic inflammation by interaction with other substances and cells that participate in the pathogenesis of neurogenic inflammation, including substance P, bradykinin, and mast cells. Collectively, these observations indicate that estrogen has the capacity to influence the onset and course of neurogenic inflammation of the bladder. (C) 2001, Elsevier Science Inc.