Apolipoprotein E gene polymorphisms are associated with carotid plaque formation but not with intima-media wall thickening - Results from the Perth Carotid Ultrasound Disease Assessment Study (CUDAS)
Apolipoprotein E gene polymorphisms are associated with carotid plaque formation but not with intima-media wall thickening - Results from the Perth Carotid Ultrasound Disease Assessment Study (CUDAS)
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DOI：
10.1161/01.str.0000062901.54157.12
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发表时间：
2003-04-01
期刊：
影响因子：
8.3
通讯作者：
Hung, J
中科院分区：
文献类型：
--
作者：
Beilby, JP;Hunt, CCJ;Hung, J
背景和目的：一些研究调查了载脂蛋白E（apoE）多态性对颈动脉内膜中层厚度（IMT）的作用，但结果相互矛盾。本研究的目的是使用一个大型的，以社区为基础的人群，以调查载脂蛋白E基因多态性和心血管疾病相关表型之间的关联：IMT，颈动脉斑块，方法随机选择1109名社区受试者，测定其ApoE基因型，结果多因素分析显示，男性（P =0.03）和女性（P = 0.05）apoE基因型与LDL-C水平之间存在相关性，男性（P = 0.05）和女性（P = 0.05）apoE基因型与LDL-C水平之间存在相关性，女性（P = 0.05）与LDL-C水平之间存在相关性，男性（P= 0.05）与LDL-C水平之间存在相关性，女性（P= 0.05）与LDL-C水平之间存在相关性，女性（P = 0.05）与LDL-C水平之间存在相关性。
Background and Purpose-Several studies have investigated the role of apolipoprotein E (apoE) polymorphisms on carotid intima-media thickness (IMT) with conflicting results. The objective of this study was to use a large, community-based population to investigate associations between apoE gene polymorphisms and cardiovascular disease-associated phenotypes: IMT, carotid artery plaque, and low- (LDL-C) and high-density lipoprotein cholesterol (HDL-C).Methods-ApoE genotypes were determined in 1109 randomly selected community subjects with an equal man-to-woman ratio and equal numbers in each age decile who were 27 to 77 years of age and had bilateral carotid B-mode ultrasound and cardiovascular risk factor measurements.Results-Multivariate analyses, stratified by sex, demonstrated an association between apoE genotypes and LDL-C levels in men (P=0.03) and women (P