Plasmacytoid dendritic cells induce plasma cell differentiation through type I interferon and interleukin 6
Plasmacytoid dendritic cells induce plasma cell differentiation through type I interferon and interleukin 6
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DOI：
10.1016/s1074-7613(03)00208-5
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发表时间：
2003-08-01
期刊：
影响因子：
32.4
通讯作者：
Banchereau, J
中科院分区：
文献类型：
--
作者：
Jego, G;Palucka, AK;Banchereau, J
树突状细胞（DC）启动和控制免疫应答。浆细胞样DC（pDC）代表了一种独特的DC亚群，其能够在遇到病毒时迅速释放大量的I型干扰素（IFN-α）。在这里，我们报告说，从人血液单核细胞的pDCs的消耗废除了特异性和多克隆IgG的分泌，以应对流感病毒。此外，用病毒触发的纯化的pDC诱导CD 40活化的B细胞分化为浆细胞。两种pDC细胞因子依次起作用，IFN-α产生非Ig分泌型浆母细胞，IL-6诱导其分化为Ig分泌型浆细胞。这些浆细胞显示在组织浆细胞上发现的高水平的CD 38。因此，pDC对于浆细胞和抗体应答的产生是关键的。
Dendritic cells (DCs) initiate and control immune responses. Plasmacytoid DCs (pDCs) represent a unique DC subset able to promptly release large amounts of type I interferon (IFN-alphabeta) upon viral encounter. Here we report that depletion of pDCs from human blood mononuclear cells abrogates the secretion of specific and polyclonal IgGs in response to influenza virus. Furthermore, purified pDCs triggered with virus induce CD40-activated B cells to differentiate into plasma cells. Two pDC cytokines act sequentially, with IFN-alphabeta generating non-Ig-secreting plasma blasts and IL-6 inducing their differentiation into Ig-secreting plasma cells. These plasma cells display the high levels of CD38 found on tissue plasma cells. Thus, pDCs are critical for the generation of plasma cells and antibody responses.