Rat heart mitochondria release adenosine.
Rat heart mitochondria release adenosine.
复制标题
大鼠心脏线粒体释放腺苷。
DOI：
10.1016/0006-291x(83)91096-3
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发表时间：
1983
影响因子：
3.1
通讯作者：
Mela,LM
中科院分区：
文献类型：
--
作者：
Bukoski,RD;Sparks,HV;Mela,LM
离体大鼠心脏线粒体在特定条件下释放腺苷。最低的腺苷释放发生在4°C，而最高的释放发生在丙酮酸+苹果酸或鱼藤酮存在下，在30°C。在状态3呼吸过程中，在阿糖胞苷存在下或在1799存在下，释放减弱。寡霉素仅部分减少腺苷释放。释放不受200 μM Ca++的影响，并且与低至2 μM的氧浓度无关。这些数据与腺苷通过腺嘌呤核苷酸转运蛋白从线粒体释放的假设一致，并且释放受线粒体内ATP与ADP比率的调节。
Isolated rat heart mitochondria release adenosine under specific conditions. Lowest adenosine release occurs at 4°C while highest release occurs in the presence of pyruvate + malate or rotenone at 30°C. The release is attenuated during state 3 respiration, in the presence of atractyloside or in the presence of 1799. Oligomycin only partially decreases adenosine release. Release is unaffected by 200 μM Ca++and is independent of oxygen concentration as low as 2 μM. The data are consistent with the hypothesis that adenosine is released from mitochondria via the adenine nucleotide transporter and the release is regulated by the intramitochondrial ATP to ADP ratio.