HUMAN HOMOLOGS OF A DROSOPHILA ENHANCER OF SPLIT GENE-PRODUCT DEFINE A NOVEL FAMILY OF NUCLEAR PROTEINS
HUMAN HOMOLOGS OF A DROSOPHILA ENHANCER OF SPLIT GENE-PRODUCT DEFINE A NOVEL FAMILY OF NUCLEAR PROTEINS
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DOI：
10.1038/ng1092-119
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发表时间：
1992-10-01
期刊：
影响因子：
30.8
通讯作者：
ARTAVANISTSAKONAS, S
中科院分区：
文献类型：
--
作者：
STIFANI, S;BLAUMUELLER, CM;ARTAVANISTSAKONAS, S
Notch和分裂增强子（E（spl））复合物的m9/10基因（groucho）是“Notch组”基因的成员，其是果蝇中多种细胞命运选择所需的。我们已经表征了编码蛋白质家族的人cDNA克隆，命名为TLE，其与E（spl）m9/10基因产物同源，以及一种新的Notch相关蛋白。TLE基因差异表达，编码核蛋白，与核功能相关的序列基序的存在一致。一个以上的TLE和Notch同源基因的存在所暗示的结构冗余可能是发育重要的果蝇Notch组基因的人类对应物的一个特征。
Notch and the m9/10 gene (groucho) of the Enhancer of split (E(spl)) complex are members of the "Notch group" of genes, which is required for a variety of cell fate choices in Drosophila. We have characterized human cDNA clones encoding a family of proteins, designated TLE, that are homologous to the E(spl) m9/10 gene product, as well as a novel Notch-related protein. The TLE genes are differentially expressed and encode nuclear proteins, consistent with the presence of sequence motifs associated with nuclear functions. The structural redundancy implied by the existence of more than one TLE and Notch-homologous gene may be a feature of the human counterparts of the developmentally important Drosophila Notch group genes.