Association of working conditions and lifestyle with increased serum gamma-glutamyltransferase: A follow-up study
Association of working conditions and lifestyle with increased serum gamma-glutamyltransferase: A follow-up study
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DOI：
10.1016/j.arcmed.2005.03.027
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发表时间：
2005-09-01
影响因子：
7.7
通讯作者：
Nogawa, K
中科院分区：
文献类型：
--
作者：
Higashikawa, A;Suwazono, Y;Nogawa, K
背景本研究调查了日本工人的工作条件和生活方式与血清γ-谷氨酰转移酶（GGT）升高的关系。对1992年至1996年期间接受第一次年度健康检查的某电信企业工人进行了跟踪研究，当时他们的年龄在40岁至54岁之间。第一次体检时血清GGT高（男性>= 60 IU/L，女性>= 30 IU/L）、既往病史或当前疾病的工人被排除在分析之外。这项研究总共包括15，586名工人。采用混合Logistic回归分析探讨工作条件、生活方式与血清GGT升高（男性>= 60 IU/L，女性>= 30 IU/L）的关系。在男性中，体重指数，饮酒（< 2次/周，2-5次/周，> 5次/周），吸烟（< 20支/天，>= 20支/天），很少吃一日三餐，明显偏好咸食，很少偏好蔬菜与血清GGT升高呈正相关。偏好高脂肪膳食（显著，中度）与血清GGT升高呈负相关。在女性中，年龄和BMI与血清GGT升高呈正相关。对这项为期5年的回顾性队列研究应用新的统计分析，我们揭示了饮酒、吸烟和饮食习惯对血清GGT升高的健康影响。另一方面，本研究表明轮班工作或其他工作条件不是血清GGT升高的显著危险因素。(c)2005年IMSS。爱思唯尔公司出版。
Background. This study investigated the association of working conditions and lifestyle with the development of increased serum gamma-glutamyltransferase (GGT) in Japanese workers.Methods. A follow-up study was carried out on workers of a telecommunication enterprise who received their first annual health check-up between 1992 and 1996, when they were between 40 and 54 years of age. Workers who had high serum GGT (>= 60 IU/L in males, >= 30 IU/L in females), a past history of disease, or current illness at their first check-up were excluded from the analysis. In total, the study included 15,586 workers. The association between working conditions and lifestyle and development of increased serum GGT (>= 60 IU/L in males, >= 30 IU/L in females) was investigated by pooled logistic regression analyses.Results. In males, body mass index, consumption of alcohol (< 2 times/week, 2-5 times/week, > 5 times/week), smoking (< 20 cigarettes/day, >= 20 cigarettes/day), rarely taking three meals a day, marked preference for salty meals, and little preference for vegetables were positively associated with the development of increased serum GGT. Preferences for fatty meals (marked, moderate) were negatively associated with the development of increased serum GGT. In females, age and BMI were positively associated with the development of increased serum GGT.Conclusions. Applying a new statistical analysis to this retrospective cohort study of 5 years, we revealed the health influences of alcohol consumption, smoking and eating habits on increased serum GGT. On the other hand, this study indicated that shift work or other working conditions are not significant risk factors for increased serum GGT. (c) 2005 IMSS. Published by Elsevier Inc.