Selective deamidation by tissue transglutaminase strongly enhances gliadin-specific T cell reactivity.
Selective deamidation by tissue transglutaminase strongly enhances gliadin-specific T cell reactivity.
复制标题
组织转谷氨酰胺酶的选择性脱酰胺作用强烈增强麦醇溶蛋白特异性 T 细胞反应性。
作者：
Y. van de Wal;Y. Kooy;P. V. van Veelen;S. Peña;L. Mearin;G. Papadopoulos;F. Koning
乳糜泻（CD）是由易感人群摄入麸质引起的。组织转谷氨酰胺酶（tTG）特异性抗体是CD的特征，在患者的空肠活检中观察到tTG活性增加。在这里，我们证明了tTG选择性地脱酰胺谷蛋白肽，这导致强烈增强的T细胞刺激活性。据我们所知，这是影响T细胞识别的食物蛋白的酶修饰的第一个例子。此外，这些修饰可能导致肠道中麸质特异性T细胞反应的扩增，因此可能对乳糜泻的发展很重要。
Celiac disease (CD) is caused by gluten ingestion in susceptible individuals. Tissue transglutaminase (tTG)-specific Abs are characteristic of CD, and increased tTG activity has been observed in the jejunal biopsies of patients. Here we demonstrate that tTG selectively deamidates gluten peptides, which results in strongly enhanced T cell-stimulatory activity. To our knowledge, this is the first example of an enzymatic modification of a food protein that affects T cell recognition. Moreover, these modifications may lead to the amplification of gluten-specific T cell responses in the gut and consequently may be important for the development of CD.
等位基因特异性基序表征了 HLA-DQ 与源自谷氨酸脱羧酶的糖尿病相关肽的相互作用。
DOI：
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发表时间：
1996
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
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作者：
Kwok,WW;Domeier,ML;Raymond,FC;Byers,P;Nepom,GT
通讯作者：
Nepom,GT