The first total synthesis of SB87-Cl and pestalone, novel bioactive benzophenone natural products
The first total synthesis of SB87-Cl and pestalone, novel bioactive benzophenone natural products
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DOI：
10.1016/j.tetlet.2004.05.063
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发表时间：
2004-07-05
影响因子：
1.8
通讯作者：
Nishiyama, S
中科院分区：
文献类型：
--
作者：
Iijima, D;Tanaka, D;Nishiyama, S
睾酮-5α-还原酶抑制剂SB87-CL和二苯甲酮2对MRSA(最低抑菌浓度MIC=37 ng/mL)和VRE(最低抑菌浓度78 ng/mL)表现出较好的抗菌活性，是一种新的生物活性二苯甲酮天然产物。I和2的全合成已成功完成。通过8和12的偶联，成功地获得了I和2的共同合成前体18。(C)2004爱思唯尔有限公司。版权所有。
SB87-Cl, an inhibitor of testosterone-5alpha-reductase, and pestalone 2 exhibiting effective antimicrobial activity against MRSA (MIC = 37 ng/mL) and VRE (MIC = 78 ng/mL), were novel bioactive benzophenone natural products. Total synthesis of I and 2 has been successfully accomplished. The common synthetic precursor 18 of I and 2, was Successfully obtained by the coupling of 8 with 12. (C) 2004 Elsevier Ltd. All rights reserved.