Interleukin-23 promotes the epithelial-mesenchymal transition of oesophageal carcinoma cells via the Wnt/β-catenin pathway.
Interleukin-23 promotes the epithelial-mesenchymal transition of oesophageal carcinoma cells via the Wnt/β-catenin pathway.
复制标题
DOI：
10.1038/srep08604
复制
发表时间：
2015-02-27
影响因子：
4.6
通讯作者：
Mao C
中科院分区：
文献类型：
--
作者：
Chen D;Li W;Liu S;Su Y;Han G;Xu C;Liu H;Zheng T;Zhou Y;Mao C
作为全球第八大常见恶性肿瘤，食管癌通常在其晚期转移时被诊断出来。白细胞介素(IL)-23是一种免疫调节细胞因子，最近已被确定为癌症相关因子。然而，IL-23在OC进化中的作用尚不清楚。在本研究中，我们发现IL-23在发生转移的OC患者的肿瘤中显著表达，并证明IL-23通过Wnt/β-catenin通路参与上皮-间质转化（epithelial-mesenchymal transition， EMT），促进OC细胞的迁移和侵袭。综上所述，IL-23在经EMT形成OC的过程中起着关键作用。
As the eighth most common malignant tumour worldwide, oesophageal cancer (OC) is often diagnosed during the metastasis of its advanced stage. Interleukin (IL)-23 is an immunomodulatory cytokine that has recently been identified as a cancer-associated factor. However, the role of IL-23 in the evolution of OC remains unclear. In the present study, we found that IL-23 was significantly expressed in the tumours of OC patients suffering metastasis and demonstrated that IL-23 contributed to epithelial-mesenchymal transition (EMT) through the Wnt/β-catenin pathway, promoting the migration and invasion of OC cells. In conclusion, IL-23 plays a pivotal role in the development of OC via EMT.
登录
查看更多内容
影响因子：
6.4
作者：
Ugai, S;Shimozato, O;Tagawa, M
通讯作者：
Tagawa, M
影响因子：
30.8
作者：
Nair RP;Duffin KC;Helms C;Ding J;Stuart PE;Goldgar D;Gudjonsson JE;Li Y;Tejasvi T;Feng BJ;Ruether A;Schreiber S;Weichenthal M;Gladman D;Rahman P;Schrodi SJ;Prahalad S;Guthery SL;Fischer J;Liao W;Kwok PY;Menter A;Lathrop GM;Wise CA;Begovich AB;Voorhees JJ;Elder JT;Krueger GG;Bowcock AM;Abecasis GR;Collaborative Association Study of Psoriasis
通讯作者：
Collaborative Association Study of Psoriasis
影响因子：
3.7
作者：
Thompson, Sarah K.;Ruszkiewicz, Andrew R.;Devitt, Peter G.
通讯作者：
Devitt, Peter G.
影响因子：
4
作者：
Jordà, M;Olmeda, D;Fabra, A
通讯作者：
Fabra, A
影响因子：
30.5
作者：
Volpe, Elisabetta;Servant, Nicolas;Soumelis, Vassili
通讯作者：
Soumelis, Vassili