Psychotic disorders hospitalizations associated with cannabis abuse or dependence: A nationwide big data analysis
Psychotic disorders hospitalizations associated with cannabis abuse or dependence: A nationwide big data analysis
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DOI：
10.1002/mpr.1813
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发表时间：
2019-12-05
影响因子：
3.1
通讯作者：
Freitas, Alberto
中科院分区：
文献类型：
--
作者：
Goncalves-Pinho, Manuel;Braganca, Miguel;Freitas, Alberto
目的我们的目的是描述和相关的精神障碍（PD）与大麻使用（CU）的趋势在所有葡萄牙公立医院的医院全景。我们进行了一项回顾性观察研究，分析了2000年至2015年在葡萄牙公立医院发生的所有住院病例。根据临床分类软件诊断单级659选择主要诊断为PD或精神分裂症的住院患者。与CU相关的Epilepsy由国际疾病分类第9版确定，临床修改代码304.3/305.2对应于大麻依赖/大麻滥用。在研究期间，PD和精神分裂症与CU相关的主要诊断的住院人数增加了29.4倍，从2000年的20人增加到2015年的588人，总共有3，233人住院，平均发作费用为3，500欧元。男性患者占所有发作的89.8%，出院时的平均/中位年龄分别为30.66/29.00岁。在所有主要诊断为PD或精神分裂症的住院患者中，次要诊断为CU的患者从2000年的0.87%上升到2015年的10.60%。结论：葡萄牙人口中二次诊断编码的增加和大麻消费模式的变化以及中/高剂量大麻消费者频率的增加可能解释了PD住院率的上升。
Objectives We aimed to describe and correlate the hospital panorama of psychotic disorders (PD) with cannabis use (CU) trends in all Portuguese public hospitals. Methods We conducted a retrospective observational study that analysed all hospitalizations that occurred in Portuguese public hospitals from 2000 to 2015. Hospitalizations with a primary diagnosis of PD or schizophrenia were selected based on Clinical Classification Software diagnostic single-level 659. Episodes associated with CU were identified by the International Classification of Diseases Version 9, Clinical Modification code 304.3/305.2 that correspond to cannabis dependence/cannabis abuse. Results The number of hospitalizations with a primary diagnosis of PD and schizophrenia associated with CU rose 29.4 times during the study period, from 20 to 588 hospitalizations yearly (2000 and 2015, respectively) with a total of 3,233 hospitalizations and an average episode cost of euro3,500. Male patients represented 89.8% of all episodes, and the mean/median age at discharge were 30.66/29.00 years, respectively. From all hospitalizations with a primary diagnosis of PD or schizophrenia, the ones with a secondary diagnosis of CU rose from 0.87% in 2000 to 10.60% in 2015. Conclusions The increase on secondary diagnosis coding and the change on cannabis patterns of consumption in Portuguese population with an increasing frequency of moderate/high dosage cannabis consumers may explain the rise on PD hospitalizations.