POOLING OF PLATELETS IN SPLEEN - ROLE IN PATHOGENESIS OF HYPERSPLENIC THROMBOCYTOPENIA
POOLING OF PLATELETS IN SPLEEN - ROLE IN PATHOGENESIS OF HYPERSPLENIC THROMBOCYTOPENIA
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DOI：
10.1172/jci105380
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发表时间：
1966-01-01
影响因子：
15.9
通讯作者：
ASTER, RH
中科院分区：
文献类型：
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作者：
ASTER, RH
本文用Cr ~（51）标记血小板、体外闪烁扫描、肾上腺素刺激和手术脾血血小板计数等方法研究了人血小板在体内的分布。正常情况下，约1/3的血小板聚集在脾脏中，与其余2/3的血小板交换，其余2/3的血小板均匀分布在血管系统的其余部分。肺池或“边缘”池似乎不包含人总血小板的显著部分。在脾[长破折号]galy中，脾血小板pcol可能大大增加，使得50-90%的血小板在任何给定时间都在脾中。这种从外周循环到脾脏的细胞再分布似乎足以产生血小板减少症，尽管血小板生成未受损，全身血小板量正常，血小板寿命几乎正常。脾切除术后出现的持续性血小板增多症，很大程度上是由于脾血小板池被清除所致。血小板的产生可能是由血小板破坏的速度而不是血液中的血小板浓度决定的。
The distribution of human platelets in the body was studied with Cr51- labeled platelets, external scintillation scanning, epinephrine stimulation and platelet counts on the blood of surgically removed spleens. Normally about l/3rd of the total platelet mass is concentrated in the spleen, exchanging with the remaining 2/3rds of platelets, which are evenly distributed throughout the rest of the vascular system. Pulmonary or "marginal" pools do not appear to contain a significant fraction of total platelets in man. In splenome[long dash]galy, the splenic platelet pcol may be greatly increased so that 50-90% of platelets are in the spleen at any given time. This redistribution of cells from the peripheral circulation to the spleen appears sufficient to produce thrombocytopenia despite unimpaired platelet production, normal total body platelet mass and nearly normal platelet life-span. The protracted thrombocytosis that usually follows splenectomy may be largely due, to removal of the splenic platelet pool. Platelet production is probably governed by the rate of platelet destruction rather than the platelet concentration of the blood.