Morphological differences in Parkinson's disease with and without rest tremor
Morphological differences in Parkinson's disease with and without rest tremor
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DOI：
10.1007/s00415-009-0092-2
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发表时间：
2009-02-01
影响因子：
6
通讯作者：
Waldvogel, Daniel
中科院分区：
文献类型：
--
作者：
Benninger, David H.;Thees, Sebastian;Waldvogel, Daniel
Rest tremor is a hallmark of Parkinson's disease (PD), but its pathogenesis remains incompletely understood. Nigro-striatal dopamine deficiency correlates best with bradykinesia, but not with tremor. Oscillating neurons in one or multiple localizations within the basal gangliathalamo-cortical loop may cause rest tremor, and an active contribution of the cerebellum and the cerebello-thalamo-cortical projections has been postulated.To compare the pattern of grey matter volume in PD patients with and without tremor to identify structural correlates of rest tremor.Voxel-based morphometry (VBM) of a high-resolution 3 Tesla, T1-weighted MR images, pre-processed according to an optimized protocol using SPM2, was performed in 24 patients with mild to moderate PD comparing local grey matter volume in patients with (n = 14) and without rest tremor (n = 10).Grey matter volume is decreased in the right quadrangular lobe and declive of the cerebellum in PD with tremor compared to those without (PFDR < 0.05).These results demonstrate for the first time morphological changes in the cerebellum in PD patients with rest tremor and highlight the involvement of the cerebellum and cerebello- thalamo-cortical circuit in the pathogenesis of parkinsonian rest tremor.
