Effects of lifestyle modification on central blood pressure in overweight and obese men
Effects of lifestyle modification on central blood pressure in overweight and obese men
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DOI：
10.1097/mbp.0000000000000006
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发表时间：
2013-12-01
影响因子：
1.3
通讯作者：
Maeda, Seiji
中科院分区：
文献类型：
--
作者：
Higashino, Ryota;Miyaki, Asako;Maeda, Seiji
最近人们认识到，中心血压升高是心血管疾病的预测因子。肥胖个体的中心血压高于非肥胖个体。然而，生活方式改变对肥胖个体中心收缩压的影响尚不清楚。本研究的目的是确定改变生活方式是否能降低超重和肥胖男性的中心血压。方法39名超重和肥胖男性（年龄492岁; BMI 301 kg/m2）被纳入本研究。我们测量了中心收缩压和臂踝脉搏波速度（baPWV），动脉僵硬度的指数，前后12周的生活方式的改变，包括有氧运动和饮食modification.ResultsAfter的12周的程序，体重，体重指数和腰部情况显着下降。超重和肥胖男性在生活方式改变后中心收缩压和baPWV显著降低。此外，生活方式改变引起的中心收缩压变化与baPWV变化之间存在显着相关性。结论该研究首次表明，生活方式改变引起的体重减轻可降低超重和肥胖男性的中心收缩压。中心收缩压的降低与动脉僵硬度的降低相关。这些结果表明，生活方式的改变引起的动脉僵硬度的降低可能有助于降低超重和肥胖男性的中心收缩压。
ObjectiveIt has recently been recognized that increased central blood pressure is a predictor of cardiovascular disease. Central blood pressure is higher in obese individuals than in nonobese individuals. However, the effect of lifestyle modification on central systolic blood pressure in obese individuals is unclear. The aim of this study was to determine whether lifestyle modification decreases central blood pressure in overweight and obese men.MethodsThirty-nine overweight and obese men (age, 492 years; BMI, 301 kg/m(2)) were recruited into our study. We measured central systolic blood pressure and brachial-ankle pulse wave velocity (baPWV), an index of arterial stiffness, before and after a 12-week lifestyle modification that included aerobic exercise and dietary modification.ResultsAfter the 12-week program, body mass, BMI, and waist circumstance decreased significantly. Central systolic blood pressure and baPWV were significantly decreased after the lifestyle modification in overweight and obese men. Furthermore, there was a significant correlation between the lifestyle modification-induced change in central systolic blood pressure and that in baPWV.ConclusionThis study showed for the first time that lifestyle modification-induced weight loss decreases central systolic blood pressure in overweight and obese men. The decrease in central systolic blood pressure was associated with the reduction in arterial stiffness. These results suggest that lifestyle modification-induced reduction in arterial stiffness may contribute toward the decreased central systolic blood pressure in overweight and obese men.