Do Rheumatoid Arthritis and Lymphoma Share Risk Factors? A Comparison of Lymphoma and Cancer Risks Before and After Diagnosis of Rheumatoid Arthritis
Do Rheumatoid Arthritis and Lymphoma Share Risk Factors? A Comparison of Lymphoma and Cancer Risks Before and After Diagnosis of Rheumatoid Arthritis
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DOI：
10.1002/art.27402
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发表时间：
2010-05-01
影响因子：
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通讯作者：
Askling, Johan
中科院分区：
文献类型：
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作者：
Hellgren, Karin;Smedby, Karin E.;Askling, Johan
目标。类风湿性关节炎（RA）患者，特别是那些病情最严重的患者，患恶性淋巴瘤的风险增加。这种增加是否完全是类风湿性关节炎疾病和/或其治疗的结果，还是反映了对这两种疾病的共同易感性尚不清楚。我们进行这项研究是为了评估RA患者在诊断为RA之前是否已经有淋巴瘤或其他癌症的风险增加，以及自RA诊断以来相对风险是否随着时间的推移而增加。偶发RA患者（症状持续时间）
Objective. Patients with rheumatoid arthritis (RA), in particular those with the most severe disease, are at increased risk of developing malignant lymphoma. Whether this increase is entirely a consequence of the RA disease and/or its treatment or is reflective of shared susceptibility to the two diseases remains unclear. We undertook this study to assess whether patients with RA are already at increased risk of lymphoma or of other cancers before the diagnosis of RA, and if the relative risk increases with time since RA diagnosis.Methods. Patients with incident RA (symptom duration