Effective sites by sympathetic beta-adrenergic and vagal nonadrenergic inhibitory stimulation in constricted airways.
Effective sites by sympathetic beta-adrenergic and vagal nonadrenergic inhibitory stimulation in constricted airways.
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收缩气道中交感β-肾上腺素能和迷走神经非肾上腺素能抑制刺激的有效部位。
DOI：
10.1164/arrd.1985.132.5.1113
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发表时间：
1985
期刊：
影响因子：
--
通讯作者：
T. Takishima
中科院分区：
文献类型：
--
作者：
N. Matsumoto;H. Inoue;M. Ichinose;M. Ishii;Chieko Inoue;H. Sasaki;T. Takishima
为了确定非肾上腺素能抑制性神经调节在呼吸道中的位置和性质，我们研究了神经系统逆转沿不同世代呼吸道的支气管收缩的相对有效性，方法是将其与9只猫的交感神经(β-肾上腺素能)刺激相比较。给予阿托品(3 mg/kg)后，雾化吸入钽粉后拍摄X线片，测量气道大小。然后静脉注射5-羟色胺(50-250微克/公斤/分钟)诱发基线支气管收缩。电刺激交感神经可抑制直径小于0.5 mm的气管至细支气管处的收缩，以直径1~4 mm时作用最大。用心得安(2 mg/kg)阻断肾上腺素能抑制神经系统后刺激迷走神经。剩余的非肾上腺素能抑制神经对5-羟色胺引起的气道收缩的作用的分布和效力与交感神经刺激的作用相当。我们的结论是，非肾上腺素能抑制神经优先扩张中等大小的呼吸道，这本质上对应于在没有阿托品的情况下刺激迷走神经而最大程度地收缩的部位。最大的(气管)和周围的气管(直径小于1毫米)只受到任何一种抑制系统的轻微影响。
In an attempt to identify the site and nature of nonadrenergic inhibitory nervous regulation in airways, we studied the relative effectiveness of the nervous system in reversing bronchoconstriction along various generations of airways by comparing it with that seen during sympathetic (beta-adrenergic) stimulation in 9 cats. After giving atropine (3 mg/kg), airway dimensions were obtained from roentgenograms after insufflation of powdered tantalum. Baseline bronchoconstriction was then induced by an intravenous infusion of serotonin (50 to 250 micrograms/kg/min). Electrical stimulation of the sympathetic nerves inhibited constriction throughout the airways from trachea down to bronchioli less than 0.5 mm in diameter, with the maximal effect in airways 1 to 4 mm in diameter. The vagi were then stimulated after blocking the adrenergic inhibitory nervous system with propranolol (2 mg/kg). The distribution and potency of the remaining nonadrenergic inhibitory nerve's effect on airway constriction induced by serotonin was comparable to that obtained with sympathetic stimulation. We conclude that the nonadrenergic inhibitory nerves preferentially dilate the midsized airways, which essentially correspond to the sites maximally constricted by vagal stimulation without atropine. The largest (tracheal) and the peripheral airways (less than 1 mm in diameter) are only slightly affected by either inhibitory system.