Acidic receptor domains on both sides of the outer membrane mediate translocation of precursor proteins into yeast mitochondria
Acidic receptor domains on both sides of the outer membrane mediate translocation of precursor proteins into yeast mitochondria
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DOI：
10.1002/j.1460-2075.1995.tb00322.x
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发表时间：
1995-12-15
期刊：
影响因子：
11.4
通讯作者：
Lithgow, T
中科院分区：
文献类型：
--
作者：
Bolliger, L;Junne, T;Lithgow, T
在胞质溶胶中产生的线粒体前体蛋白与线粒体表面上的异源寡聚蛋白输入受体结合，然后穿过跨外膜的易位通道。该易位步骤由突出到膜间隙中的受体亚基Mas22p的酸性结构域加速。
Mitochondrial precursor proteins made in the cytosol bind to a hetero-oligomeric protein import receptor on the mitochondrial surface and then pass through the translocation channel across the outer membrane, This translocation step is accelerated by an acidic domain of the receptor subunit Mas22p, which protrudes into the intermembrane space, This 'trans' domain of Mas22p specifically binds functional mitochondrial targeting peptides with a K-d Of