GATA-1: One protein, many partners
GATA-1: One protein, many partners
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DOI：
10.1016/j.biocel.2005.06.017
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发表时间：
2006-01-01
影响因子：
4
通讯作者：
Mackay, JP
中科院分区：
文献类型：
--
作者：
Lowry, JA;Mackay, JP
GATA-1是GATA转录因子家族的创始成员，在红细胞和巨核细胞谱系中对细胞成熟和分化至关重要。GATA-1调节这些谱系中许多基因的表达，其功能取决于其结合DNA和蛋白质伴侣的能力。这些功能的任何一种破坏都会导致严重的造血功能障碍，并导致血液疾病，如血小板减少症和贫血。在这篇综述中，我们将重点关注GATA-1的结构方面，包括与许多合作伙伴的相互作用，以及确定破坏这些相互作用的几种突变。(c) 2005 Elsevier Ltd版权所有。
GATA-1, the founding member of the GATA transcription factor family, is essential for cell maturation and differentiation within the erythroid and megakaryocytic lineages. GATA-1 regulates the expression of many genes within these lineages and its functionality depends upon its ability to bind both DNA and protein partners. Disruption of either of these functions causes severe hematopoietic dysfunction and results in blood disorders, such as thrombocytopenia and anemia. Within this review, we will focus on the structural aspects of GATA-1 with regard to interactions with its many partners and the identification of several mutations that disrupt these interactions. (c) 2005 Elsevier Ltd. All rights reserved.