Association of gray matter volumes with general and specific dimensions of psychopathology in children
Association of gray matter volumes with general and specific dimensions of psychopathology in children
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DOI：
10.1038/s41386-020-00952-w
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发表时间：
2021-01-21
影响因子：
7.6
通讯作者：
Kaczkurkin, Antonia N.
中科院分区：
文献类型：
--
作者：
Durham, E. Leighton;Jeong, Hee Jung;Kaczkurkin, Antonia N.
儿童期是精神病理表现的重要时期。精神病理学的特征是相当多的共病性，这反映在精神病理学的潜在神经相关性中。在成人和青年样本中，在多种精神障碍中发现了脑容量的常见和可分离的变化。然而，这些研究中的大多数使用了年龄范围较宽的样本，这可能会掩盖发育差异。目前的研究探讨了区域灰质体积（GMV）和精神病理学之间的关联，在一个狭窄的年龄范围的儿童大样本。我们使用了9607名9-10岁儿童的数据，这些数据是青少年大脑认知发展（SM）研究（ABCD研究（R））的一部分。一个双因素模型确定了一个一般的精神病理因素，反映了常见的差异，在疾病和具体因素代表内化症状，多动症症状，和行为问题。使用3 T MRI获取脑体积。经多重检验校正后，结构方程模型显示，区域GMV与一般精神病理学和行为问题之间几乎呈全球性负相关，ADHD症状也存在相关性（p（fdr）值
Childhood is an important time for the manifestation of psychopathology. Psychopathology is characterized by considerable comorbidity which is mirrored in the underlying neural correlates of psychopathology. Both common and dissociable variations in brain volume have been found across multiple mental disorders in adult and youth samples. However, the majority of these studies used samples with broad age ranges which may obscure developmental differences. The current study examines associations between regional gray matter volumes (GMV) and psychopathology in a large sample of children with a narrowly defined age range. We used data from 9607 children 9-10 years of age collected as part of the Adolescent Brain Cognitive Development(SM) Study (ABCD Study(R)). A bifactor model identified a general psychopathology factor that reflects common variance across disorders and specific factors representing internalizing symptoms, ADHD symptoms, and conduct problems. Brain volume was acquired using 3T MRI. After correction for multiple testing, structural equation modeling revealed nearly global inverse associations between regional GMVs and general psychopathology and conduct problems, with associations also found for ADHD symptoms (p(fdr)-values