Dietary fenretinide, a synthetic retinoid, decreases the tumor incidence and the tumor mass of ras+myc-induced carcinomas in the mouse prostate reconstitution model system.
Dietary fenretinide, a synthetic retinoid, decreases the tumor incidence and the tumor mass of ras+myc-induced carcinomas in the mouse prostate reconstitution model system.
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发表时间：
1993-10
期刊：
影响因子：
11.2
通讯作者：
K. Slawin;D. Kadmon;S. Park;P. T. Scardino;M. Anzano;Michael B. Sporn;Timothy C. Thompson
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文献类型：
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作者：
K. Slawin;D. Kadmon;S. Park;P. T. Scardino;M. Anzano;Michael B. Sporn;Timothy C. Thompson
一些流行病学研究表明，饮食和血清中视黄醇含量低会增加患前列腺癌的风险。在最近的一份报告中，膳食芬维甲酸[N-[（4-羟基苯基）]维甲酸]，一种低毒性的合成类维甲酸，降低了实验诱导的前列腺癌的发病率。芬瑞啶目前正在I期和II期临床试验中作为治疗和化学预防人类前列腺癌的药物进行评估。由于这些发现，我们研究了膳食芬维啶是否可以改变癌基因诱导的前列腺癌在小鼠前列腺重建模型系统中的表型发生率。与对照组相比，在小鼠前列腺重建模型系统中，膳食芬维甲酸可使ras+myc诱导的肿瘤发病率降低49%，肿瘤体积减少52%，并延长了癌症发展前的潜伏期。类维生素a对细胞分化、生长因子合成和免疫功能有广泛的影响。虽然其在该系统中的作用机制尚不清楚，但在小鼠前列腺重建模型系统中，芬瑞啶是一种有效的癌基因诱导前列腺癌的化学预防和生长调节药物，可能对人类前列腺癌的化学预防有效。
Several epidemiological studies have implicated low dietary and serum levels of retinol with an increased risk for the development of human prostate cancer. In a recent report, dietary fenretinide [N-[(4-hydroxyphenyl)] retinamide], a synthetic retinoid with low toxicity, decreased the incidence of experimentally induced prostate cancer. Fenretinide is currently being evaluated in phase I and phase II clinical trials as an agent for both the treatment and chemoprevention of human prostate cancer. Because of these findings, we investigated whether dietary fenretinide could alter the incidence of phenotype of oncogene-induced prostate cancer in the mouse prostate reconstitution model system. When compared to control-fed animals, dietary fenretinide reduced the tumor incidence by 49% and the tumor mass by 52% of ras+myc-induced cancers in the mouse prostate reconstitution model system, which was modified to prolong the latency period before cancer development. Retinoids have a wide ranging effect on cellular differentiation, growth factor synthesis, and immune function. While its mechanism of action in this system remains unclear, fenretinide is an effective agent for the chemoprevention and growth modulation of oncogene-induced prostate cancer in the mouse prostate reconstitution model system and may be effective for the chemoprevention of human prostate cancer.