Murine Anorectic Response to Deoxynivalenol (Vomitoxin) Is Sex-Dependent.
Murine Anorectic Response to Deoxynivalenol (Vomitoxin) Is Sex-Dependent.
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DOI：
10.3390/toxins7082845
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发表时间：
2015-07-29
期刊：
影响因子：
4.2
通讯作者：
Pestka JJ
中科院分区：
文献类型：
--
作者：
Clark ES;Flannery BM;Pestka JJ
脱氧雪腐镰刀菌烯醇(DON，呕吐毒素)是谷物食品中常见的一种三环烯类真菌毒素，可调节免疫功能和维持能量平衡。这项研究的目的是确定在小鼠的唐氏厌食反应中，性别差异是否同样明显。我们实验室以前开发的饲料拒绝生物测定法被用来比较急性IP。1 mg/kg和5 mg/kg体重染毒对C57BL6小鼠的毒性作用雄鼠的厌食反应比雌鼠更强。在急性暴露时，雄性小鼠的器官和血浆DON浓度高于雌性小鼠。男性的IL-6血浆水平也显著升高，而女性的胆囊收缩素反应更高。当比较性别对食物摄入量和体重变化的影响后，在亚慢性饮食暴露于1，2.5和10ppm DON后，男性再次被发现更敏感。证明男性对DON引起的食物摄入量和体重增加的改变的偏好可能是未来DON和其他三氯乙烯风险评估中的一个重要考虑因素。
Deoxynivalenol (DON, vomitoxin), a common trichothecene mycotoxin found in cereal foods, dysregulates immune function and maintenance of energy balance. The purpose of this study was to determine if sex differences are similarly evident in DON’s anorectic responses in mice. A bioassay for feed refusal, previously developed by our lab, was used to compare acute i.p. exposures of 1 and 5 mg/kg bw DON in C57BL6 mice. Greater anorectic responses were seen in male than female mice. Male mice had higher organ and plasma concentrations of DON upon acute exposure than their female counterparts. A significant increase in IL-6 plasma levels was also observed in males while cholecystokinin response was higher in females. When effects of sex on food intake and body weight changes were compared after subchronic dietary exposure to 1, 2.5, and 10 ppm DON, males were found again to be more sensitive. Demonstration of male predilection to DON-induced changes in food intake and weight gain might an important consideration in future risk assessment of DON and other trichothecenes.