Seasonal variation in serum cholesterol levels - Treatment implications and possible mechanisms
Seasonal variation in serum cholesterol levels - Treatment implications and possible mechanisms
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DOI：
10.1001/archinte.164.8.863
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发表时间：
2004-04-26
影响因子：
--
通讯作者：
Hebert, JR
中科院分区：
文献类型：
--
作者：
Ockene, IS;Chiriboga, DE;Hebert, JR
背景：各种研究都注意到血脂水平的季节性变化。虽然这种现象的机制尚不清楚，但这种变化可能导致更多的人在冬季被诊断为患有高胆固醇血症。方法：我们对来自马萨诸塞州中部健康维护组织的517名健康志愿者的脂质水平的季节性变化进行了纵向研究。在12个月期间收集的每个人的数据包括基线人口统计学和季度人体测量，血脂，饮食，体力活动，光照和行为信息。结果：男性平均总胆固醇水平为222 mg/dL（5.75 mmol/L），女性为213 mg/dL（5.52 mmol/L）。男性的季节变化幅度为3.9 mg/dL（0.10 mmol/L），峰值在12月，女性为5.4 mg/dL（0.14 mmol/L），峰值在1月。高胆固醇血症参与者的季节性幅度更大。血浆容量的季节性变化解释了所观察到的变化的很大一部分。总体而言，22%以上的参与者总胆固醇水平为240 mg/dL或更高（大于或等于6.22 mmol/L），在冬季比在summer.Conclusions：这项研究证实了血脂水平的季节性变化，并建议在妇女和高胆固醇血症的个人，更大幅度的季节性变异，血浆容量的变化占很大的变化。在夏季，相对的血浆高血容量似乎与温度和/或体力活动的增加有关。这些发现对脂质筛查指南有影响。需要进一步的研究来更好地了解相对冬季血液浓缩的影响。
Background: A variety of studies have noted seasonal variation in blood lipid levels. Although the mechanism for this phenomenon is not clear, such variation could result in larger numbers of people being diagnosed as having hypercholesterolemia during the winter.Methods: We conducted a longitudinal stud), of seasonal variation in lipid levels in 517 healthy volunteers from a health maintenance organization serving central Massachusetts. Data collected during a 12-month period for each individual included baseline demographics and quarterly anthropometric, blood lipid, dietary, physical activity, light exposure, and behavioral information. Data were analyzed using sinusoidal regression modeling techniques.Results: The average total cholesterol level was 222 mg/dL (5.75 mmol/L) in men and 213 mg/dL (5.52 mmol/L) in women. Amplitude of seasonal variation was 3.9 mg/dL (0.10 mmol/L) in men, with a peak in December, and 5.4 mg/dL (0.14 mmol/L) in women, with a peak in january. Seasonal amplitude was greater in hypercholesterolemic participants. Seasonal changes in plasma volume explained a substantial proportion of the observed variation. Overall, 22% more participants had total cholesterol levels of 240 mg/dL or greater ( greater than or equal to6.22 mmol/L) in the winter than in the summer.Conclusions: This study confirms seasonal variation in blood lipid levels and suggests greater amplitude in seasonal variability in women and hypercholesterotemic individuals, with changes in plasma volume accounting for much of the variation. A relative plasma hypervolemia during the summer seems to be linked to increases in temperature and/or physical activity. These findings have implications for lipid screening guidelines. Further research is needed to better understand the effects of a relative winter hemoconcentration.