Anticholinesterase-induced cholinergic subsensitivity in primate accommodative mechanism.
Anticholinesterase-induced cholinergic subsensitivity in primate accommodative mechanism.
复制标题
灵长类动物调节机制中抗胆碱酯酶诱导的胆碱能亚敏感性。
DOI：
10.1016/s0002-9394(14)77094-1
复制
发表时间：
1978
影响因子：
4.2
通讯作者：
P. Kaufman
中科院分区：
文献类型：
--
作者：
P. Kaufman
我对食蟹猴进行了连续几个月每日两次的局部碘化氢硫酸治疗。在睫状神经节或胆碱能神经阻断后，局部或肌肉内注射匹罗卡品的调节反应被确定。在超声硫酸盐治疗期间，肌肉注射匹罗卡品剂量很少或没有调节反应，而在未超声硫酸盐治疗的眼睛中，匹罗卡品剂量接近最大。同样，在未治疗的眼睛中，当局部匹罗卡平剂量超过最大剂量的50倍时，回声硫酸盐治疗的眼睛表现出很少或没有反应。停药后两周内，肌肉注射匹罗卡品的适应性反应明显恢复，停药后七周，肌肉注射匹罗卡品的敏感性增加到对照水平的30 - 50%。这些发现与乙酰胆碱诱导的睫状肌胆碱能亚敏感是一致的。
I treated cynomolgus monkeys with topical echothiophate iodide twice daily for several months. Accommodative responses to topical or intramuscular pilocarpine were determined after ciliary ganglion or cholinergic nerve blockade. During echothiophate treatment, there was little or no accommodative response to intramuscular pilocarpine doses which were near maximal in nonechothiophate-treated eyes. Similarly, echothiophate-treated eyes demonstrated little or no response to topical pilocarpine doses that were more than 50 times supramaximal in nontreated eye. Within two weeks after stopping echothiophate, accommodative responses to intramuscular pilocarpine had returned noticeably, and by seven weeks after stopping echothiophate, sensitivity to intramuscular pilocarpine had increased to 30 to 50% of control levels. The findings are compatible with acetylcholine-induced cholinergic subsensitivity of the ciliary muscle.