In vivo dynamic human retinal blood flow imaging using ultra-high-speed spectral domain optical Doppler tomography
In vivo dynamic human retinal blood flow imaging using ultra-high-speed spectral domain optical Doppler tomography
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DOI：
10.1364/oe.11.003490
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发表时间：
2003-12-15
期刊：
影响因子：
3.8
通讯作者：
de Boer, JF
中科院分区：
文献类型：
--
作者：
White, BR;Pierce, MC;de Boer, JF
使用超高速谱域光学多普勒层析成像（SD-ODT）系统以每秒29，000个深度轮廓（A线）的速度采集活体内人视网膜中的血流图像，并且在99%的测量时间内采集数据.的相位稳定性的系统进行检查和图像处理算法，允许准确的双向多普勒频移的测定。电影呈现了在3.28秒的时间段内以每秒29帧、每帧1000条A线获得的人类视网膜流动，显示了血管边界的准确确定和动脉-静脉对中的时间依赖性双向流动动力学.超高速SD- ODT系统允许可视化视网膜血流的脉动性质，检测脉络膜和视网膜毛细血管内的血流，并提供心动周期的信息。总之，视网膜血流动力学的精确视频速率成像在低于600 μ W的眼部暴露水平下被证明。(C)2003年美国光学学会。
An ultra- high- speed spectral domain optical Doppler tomography ( SD- ODT) system is used to acquire images of blood flow in a human retina in vivo, at 29,000 depth profiles ( A- lines) per second and with data acquisition over 99% of the measurement time. The phase stability of the system is examined and image processing algorithms are presented that allow accurate determination of bi- directional Doppler shifts. Movies are presented of human retinal flow acquired at 29 frames per second with 1000 A- lines per frame over a time period of 3.28 seconds, showing accurate determination of vessel boundaries and time- dependent bi- directional flow dynamics in artery- vein pairs. The ultra- high- speed SD- ODT system allows visualization of the pulsatile nature of retinal blood flow, detects blood flow within the choroid and retinal capillaries, and provides information on the cardiac cycle. In summary, accurate video rate imaging of retinal blood flow dynamics is demonstrated at ocular exposure levels below 600 muW. (C) 2003 Optical Society of America.