The effect of whole-body vibration on peri-implant bone healing in rats
The effect of whole-body vibration on peri-implant bone healing in rats
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DOI：
10.1111/j.1600-0501.2010.02020.x
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发表时间：
2011-03-01
影响因子：
4.3
通讯作者：
Duyck, Joke
中科院分区：
文献类型：
--
作者：
Ogawa, Toru;Zhang, Xiaolei;Duyck, Joke
目的研究全身振动（WBV）低强度高频（LMHF）载荷对大鼠胫骨种植体周围骨愈合和种植体骨融合的影响。材料与方法将42只大鼠胫骨近端干骺端置入定制钛种植体，静置愈合3、7、14、25天。其中一半的动物每周接受5天的LMHF机械振动（测试），而其余的动物作为卸载的对照组。WBV由15个连续的频率步长(12,20,30，…至150hz)。15个频率中的每一个都以0.3 g的加速度进行2000次循环。在愈合期为25天的组中，注射正电子发射示踪剂[18F]氟化钠后，于加载后第1天（术前第1天）、第3天、第5天、第7天、第10天、第14天和第21天拍摄PET图像。植入物周围的代谢活动与参考部位的代谢活动之比（摄取比）被计算为骨代谢的量度。对骨与种植体接触（BIC）和种植体周围骨分数（BF）进行组织形态学测量。结果负荷和愈合时间对平均BIC和BF均有显著影响（方差分析，P < 0.01）。PET图像没有显示测试和对照植入物之间摄取比有任何显著差异。结论lmhf的添加显著提高了BIC和BF。结果证实了LMHF负载通过WBV对种植体周围骨愈合和骨整合的骨刺激潜力。引用本文：Ogawa T， Zhang X, Naert I, Vermaelen P. Deroose CM, Sasaki K, Duyck J.全身振动对大鼠种植体周围骨愈合的影响。口服Impl。Res. 22, 2011；302 - 307。doi: 10.1111 / j.1600-0501.2010.02020.x。
PurposeThe aim of this study was to evaluate the effect of low-magnitude, high-frequency (LMHF) loading, applied by means of whole-body vibration (WBV), on peri-implant bone healing and implant osseointegration in rat tibiae.Materials and methodsA custom-made titanium implant was inserted into the proximal metaphysis of the tibiae of 42 rats and left to heal for 3, 7, 14 or 25 days. Half of the animals received LMHF mechanical vibration for 5 days per week (test), whereas the others served as unloaded controls. The WBV consisted of 15 consecutive frequency steps (12, 20, 30, ... to 150 Hz). Each of the 15 frequencies was applied for 2000 cycles, at an acceleration of 0.3 g. In the group with a 25-day healing period, PET images were taken at -1 (day before surgery), 3, 5, 7, 10, 14 and 21 days of loading, after an injection of [18F]sodium fluoride, a positron-emitting tracer. The ratio of the metabolic activity around the implants to that of a reference site (uptake ratio) was calculated as a measure of bone metabolism. Bone-to-implant contact (BIC) and peri-implant bone fraction (BF) were analysed for histomorphometrical measurement.ResultsThe mean BIC and BF were significantly influenced by both the loading and the healing time (ANOVA, P < 0.01). The PET images did not reveal any significant difference in uptake ratio between the test and the control implants.ConclusionLMHF loading increased BIC and BF significantly. The results confirm the bone-stimulating potential of LMHF loading, through WBV, on peri-implant bone healing and osseointegration.To cite this article:Ogawa T, Zhang X, Naert I, Vermaelen P. Deroose CM, Sasaki K, Duyck J. The effect of whole-body vibration on peri-implant bone healing in rats.Clin. Oral Impl. Res. 22, 2011; 302-307.doi: 10.1111/j.1600-0501.2010.02020.x.