Telocytes, a distinct type of cell among the stromal cells present in the lamina propria of jejunum
Telocytes, a distinct type of cell among the stromal cells present in the lamina propria of jejunum
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DOI：
10.14670/hh-27.1067
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发表时间：
2012-08-01
影响因子：
2
通讯作者：
Popescu, L. M.
中科院分区：
文献类型：
--
作者：
Cretoiu, D.;Cretoiu, Sanda M.;Popescu, L. M.
通常，肠壁基质中描述的细胞是成纤维细胞/纤维细胞、肥大细胞、浆细胞、嗜酸性粒细胞、巨噬细胞和Cajal间质细胞（ICC），后者被认为是胃肠节律的起搏器。最近，在各种空腔和非空腔器官中发现了一种称为端细胞（TC）的新型基质细胞（www.telocytes.com）。我们在这里显示直接的电子显微镜证据TC的存在下，在大鼠空肠固有层的粘膜隐窝上皮层和粘膜肌层的平滑肌细胞（SMCs）之间。TC的特征在于：几个非常长的（几十到几百μ m）的突起，称为telopodes（Tps）。TPS（其口径低于光学显微镜的分辨能力）显示了豆荚粒（细节
Conventionally, cells described in the stroma of the intestinal wall are fibroblasts/fibrocytes, mast cells, plasma cells, eosinophils, macrophages and, interstitial cells of Cajal (ICCs), the latter being considered as the pacemakers of gastrointestinal rhythmicity. Recently, a new type of stromal cell called telocyte (TCs) was found in various cavitary and non-cavitary organs (www.telocytes.com). We show here direct electron microscopical evidence for the presence of TCs in the lamina propria of rat jejunum just beneath the epithelial layer of the mucosal crypts and in between the smooth muscle cells (SMCs) of muscularis mucosae. TCs are characterized by: several very long (tens to hundreds of mu m) prolongations called telopodes (Tps). Tps (with caliber below the resolving power of light microscopy) display podomeres (thin segments