Lack of flow regulation may explain the development of arteriovenous malformations
Lack of flow regulation may explain the development of arteriovenous malformations
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DOI：
10.1179/016164101101198938
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发表时间：
2001-09-01
影响因子：
1.9
通讯作者：
Young, WL
中科院分区：
文献类型：
--
作者：
Quick, CM;Hashimoto, T;Young, WL
在正常的脉管系统中，尺寸大不相同的血管将剪切应力维持在窄范围内。最近，研究人员已经取得了很大的成功，利用数学模型来探讨正常血管床的结构与功能的关系，当研究人员首次探讨血管床如何适应设置在适当的水平剪切应力，然而，一些血管往往会倒退，一些往往会成长为动静脉分流。在模型中加入流量调节后，可防止动脉树退化。目前的工作探讨了这一理论发展的含义，并说明了它如何可能解释动静脉畸形（AVM）的成因。我们使用一个简单的模型来说明如何削弱血流的局部控制导致模型变得结构不稳定，产生类似于AVM的结构和行为。这项工作表明，缺乏局部血流控制是动静脉畸形的原因，而不仅仅是结果。从这种建模方法中获得的洞察力，可以设计具体的，有针对性的实验。
In the normal vasculature, vessels of widely different sizes maintain shear stress within a narrow range. Recently, investigators have had great success using mathematical models to explore the relationship of structure to function in normal vascular beds, When investigators first explored how vascular beds adapt to set shear stress at appropriate levels, however, some vessels tended to regress, and some tended to grow into arteriovenous shunts. Degeneration of the arterial tree is prevented when flow regulation is added to the model. The present work explores the implication of this theoretical development and illustrates how it may explain the genesis of arteriovenous malformations (AVMs). We use a simple model to illustrate how impairing local control of blood flow causes models to become structurally unstable, yielding a structure and behavior similar to AVMs. This work shows how the lack of local flow control can be the cause, not just the result, of arteriovenous malformations. With insight gained from this modeling approach, specific, focused experiments can be designed.