A Wolbachia Symbiont in Aedes aegypti Limits Infection with Dengue, Chikungunya, and Plasmodium
A Wolbachia Symbiont in Aedes aegypti Limits Infection with Dengue, Chikungunya, and Plasmodium
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DOI：
10.1016/j.cell.2009.11.042
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发表时间：
2009-12-24
期刊：
影响因子：
64.5
通讯作者：
O'Neill, Scott L.
中科院分区：
文献类型：
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作者：
Moreira, Luciano A.;Iturbe-Ormaetxe, Inaki;O'Neill, Scott L.
沃尔巴克氏体是母系遗传的细胞内细菌共生体，估计感染超过60%的所有昆虫物种。虽然沃尔巴克氏体通常存在于许多蚊子中，但被认为对人类病原体传播至关重要的物种中却没有。最近有报道称，成功地将一种缩短寿命的沃尔巴克氏体菌株引入登革热病媒埃及伊蚊，使其成年寿命减半。在这里，我们表明，同样的沃尔巴克氏体感染也直接抑制了一系列病原体感染这种蚊子的能力。该效应是沃尔巴克氏体菌株特异性的，并且与沃尔巴克氏体引发蚊子先天免疫系统和潜在地竞争病原体复制所需的限制性细胞资源有关。我们认为，这种沃尔巴克氏体介导的病原体干扰可能与之前提出的缩短寿命策略协同作用，为控制昆虫传播疾病提供了一种强有力的方法。
Wolbachia are maternally inherited intracellular bacterial symbionts that are estimated to infect more than 60% of all insect species. While Wolbachia is commonly found in many mosquitoes it is absent from the species that are considered to be of major importance for the transmission of human pathogens. The successful introduction of a life-shortening strain of Wolbachia into the dengue vector Aedes aegypti that halves adult lifespan has recently been reported. Here we show that this same Wolbachia infection also directly inhibits the ability of a range of pathogens to infect this mosquito species. The effect is Wolbachia strain specific and relates to Wolbachia priming of the mosquito innate immune system and potentially competition for limiting cellular resources required for pathogen replication. We suggest that this Wolbachia-mediated pathogen interference may work synergistically with the life-shortening strategy proposed previously to provide a powerful approach for the control of insect transmitted diseases.