HIV-associated Hodgkin lymphoma
HIV-associated Hodgkin lymphoma
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DOI：
10.1097/coh.0b013e32831a722b
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发表时间：
2009-01-01
影响因子：
4.1
通讯作者：
Spina, Michele
中科院分区：
文献类型：
--
作者：
Carbone, Antonino;Gloghini, Annunziata;Spina, Michele
综述的目的本综述的重点是目前对艾滋病相关霍奇金淋巴瘤（HIV-HL）的流行病学、病理学和治疗的认识。最近发现在非艾滋病定义的癌症中，最近观察到霍奇金淋巴瘤的风险增加。然而，HIV感染、艾滋病和霍奇金淋巴瘤之间的关系尚不清楚。SummaryIn高活性抗逆转录病毒治疗时代，HIV感染者似乎比流行的最初几年患霍奇金淋巴瘤的风险增加。在这些免疫力提高的患者中，增加的CD 4（+）T细胞为肿瘤细胞的免疫逃逸提供了抗凋亡途径和机制，就像在非艾滋病患者中发生的经典霍奇金淋巴瘤一样。多项研究表明，HIV感染者与非HIV感染者的霍奇金淋巴瘤亚型分布存在显著差异。HIV-HL分别表现出与细胞背景和肿瘤细胞群丰度相关的特殊特征。事实上，潜伏膜蛋白1在几乎所有的HIV-HL病例中表达，表明EB病毒在HIV-HL的发病机制中起着病因学作用。在联合治疗，这是开始显示在治疗这种艾滋病毒相关疾病的承诺，最新进展进行了讨论。
Purpose of reviewThe focus of this review is on the current knowledge on epidemiology, pathology and treatment of HIV-associated Hodgkin lymphoma (HIV-HL).Recent findingsAmong non-AIDS-defining cancers, an increased risk of Hodgkin lymphoma was recently observed. However, the relationship between HIV infection, AIDS and Hodgkin lymphoma is still unclear.SummaryIn the highly active antiretroviral therapy era, HIV-infected people seem to be at increased risk of Hodgkin lymphoma than in first years of the epidemic. In these persons with improved immunity, increased CD4(+) T cells provide antiapoptotic pathways and mechanisms for immune escape by tumor cells, as occurs in classic Hodgkin lymphoma among people without AIDS. Several studies have documented a significant difference in the distribution of Hodgkin lymphoma subtypes inHIV-infected persons as compared with Hodgkin lymphoma in HIV-uninfected population. HIV-HL exhibits special features related to the cellular background and the abundance of the neoplastic cell population, respectively. The fact that latent membrane protein 1 is expressed in virtually all HIV-HL cases suggests that Epstein-Barr virus plays an etiological role in the pathogenesis of HIV-HL. Recent advances in combined therapies, which are beginning to show promise in the treatment of this HIV-associated disorder, are discussed.