Complementary Roles for Primate Frontal and Parietal Cortex in Guarding Working Memory from Distractor Stimuli
Complementary Roles for Primate Frontal and Parietal Cortex in Guarding Working Memory from Distractor Stimuli
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DOI：
10.1016/j.neuron.2014.05.009
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发表时间：
2014-07-02
期刊：
影响因子：
16.2
通讯作者：
Nieder, Andreas
中科院分区：
文献类型：
--
作者：
Jacob, Simon Nikolas;Nieder, Andreas
前额叶皮层（PFC）和后顶叶皮层对维持工作记忆中的行为相关信息非常重要。在这里，我们挑战普遍持有的观点，即PFC神经元抑制干扰是过滤任务无关信息的主要机制。我们记录了单单位活动PFC和腹侧顶内区（VIP）的猴子训练，以抵抗分散刺激的延迟匹配到数字任务。令人惊讶的是，PFC神经元优先编码干扰在他们的介绍。然而，在这种干扰后不久，PFC神经元恢复了目标信息，这些信息预测了正确的行为决定。相比之下，大多数VIP神经元在整个试验过程中仅编码目标数字。VIP中的目标信息表征是最早和最可靠的行为相关神经元。我们的数据表明，分散注意力的刺激可以绕过存储和检索目标信息，强调积极的维护过程中的工作记忆与额叶和顶叶皮层在控制记忆内容的互补功能。
Prefrontal cortex (PFC) and posterior parietal cortex are important for maintaining behaviorally relevant information in working memory. Here, we challenge the commonly held view that suppression of distractors by PFC neurons is the main mechanism underlying the filtering of task-irrelevant information. We recorded single-unit activity from PFC and the ventral intraparietal area (VIP) of monkeys trained to resist distracting stimuli in a delayed-match-to-numerosity task. Surprisingly, PFC neurons preferentially encoded distractors during their presentation. Shortly after this interference, however, PFC neurons restored target information, which predicted correct behavioral decisions. In contrast, most VIP neurons only encoded target numerosities throughout the trial. Representation of target information in VIP was the earliest and most reliable neuronal correlate of behavior. Our data suggest that distracting stimuli can be bypassed by storing and retrieving target information, emphasizing active maintenance processes during working memory with complementary functions for frontal and parietal cortex in controlling memory content.