IL-27 Derived From Macrophages Facilitates IL-15 Production and T Cell Maintenance Following Allergic Hypersensitivity Responses.
IL-27 Derived From Macrophages Facilitates IL-15 Production and T Cell Maintenance Following Allergic Hypersensitivity Responses.
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DOI：
10.3389/fimmu.2021.713304
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发表时间：
2021
影响因子：
7.3
通讯作者：
MacLeod AS
中科院分区：
文献类型：
--
作者：
Suwanpradid J;Lee MJ;Hoang P;Kwock J;Floyd LP;Smith JS;Yin Z;Atwater AR;Rajagopal S;Kedl RM;Corcoran DL;Zhang JY;MacLeod AS
屏障组织内的暂时性白细胞簇中T细胞、树突状细胞和巨噬细胞之间的相互作用为皮肤中T细胞的激活提供了一个新概念。来自这些白细胞簇的活化T细胞在过敏性接触性皮炎（CHS）的传出阶段起着关键作用。然而，在CHS期间及之后驱动致病性T细胞维持和存活的细胞因子大多仍不明确。在经皮过敏原激发后，我们在此报道巨噬细胞产生白细胞介素 - 27（IL - 27），其进而诱导白细胞簇内的表皮角质形成细胞和真皮髓样细胞产生白细胞介素 - 15（IL - 15）。与已知的白细胞介素 - 15作为T细胞存活因子和生长细胞因子的作用一致，该信号轴增强了皮肤T细胞的BCL2表达和存活。在CHS小鼠中对白细胞介素 - 27进行基因缺失或药物阻断会导致表皮白细胞介素 - 15产生减少，从而使T细胞中BCL2表达降低以及真皮CD8 + T细胞和T细胞簇数量减少。这些发现表明白细胞介素 - 27通路是调节皮肤T细胞免疫的一种重要细胞因子。
Crosstalk between T cells, dendritic cells, and macrophages in temporal leukocyte clusters within barrier tissues provides a new concept for T cell activation in the skin. Activated T cells from these leukocyte clusters play critical roles in the efferent phase of allergic contact hypersensitivity (CHS). However, the cytokines driving maintenance and survival of pathogenic T cells during and following CHS remain mostly unknown. Upon epicutaneous allergen challenge, we here report that macrophages produce IL-27 which then induces IL-15 production from epidermal keratinocytes and dermal myeloid cells within leukocyte clusters. In agreement with the known role of IL-15 as a T cell survival factor and growth cytokine, this signaling axis enhances BCL2 and survival of skin T cells. Genetic depletion or pharmacological blockade of IL-27 in CHS mice leads to abrogated epidermal IL-15 production resulting in a decrease in BCL2 expression in T cells and a decline in dermal CD8+ T cells and T cell cluster numbers. These findings suggest that the IL-27 pathway is an important cytokine for regulating cutaneous T cell immunity.
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影响因子：
48
作者：
Huber W;Carey VJ;Gentleman R;Anders S;Carlson M;Carvalho BS;Bravo HC;Davis S;Gatto L;Girke T;Gottardo R;Hahne F;Hansen KD;Irizarry RA;Lawrence M;Love MI;MacDonald J;Obenchain V;Oleś AK;Pagès H;Reyes A;Shannon P;Smyth GK;Tenenbaum D;Waldron L;Morgan M
通讯作者：
Morgan M
影响因子：
82.9
作者：
Adachi T;Kobayashi T;Sugihara E;Yamada T;Ikuta K;Pittaluga S;Saya H;Amagai M;Nagao K
通讯作者：
Nagao K
影响因子：
2.2
作者：
Autengruber, A.;Gereke, M.;Bruder, D.
通讯作者：
Bruder, D.
影响因子：
15.3
作者：
Huang, Zhe;Zak, Jaroslav;Teijaro, John R.
通讯作者：
Teijaro, John R.
影响因子：
5.2
作者：
Chaudhry, Hafsa M.;Drage, Lisa A.;Davis, Mark D. P.
通讯作者：
Davis, Mark D. P.