Functionally distinct inhibitory neurons at the first stage of visual cortical processing
Functionally distinct inhibitory neurons at the first stage of visual cortical processing
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DOI：
10.1038/nn1152
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发表时间：
2003-12-01
影响因子：
25
通讯作者：
Sommer, FT
中科院分区：
文献类型：
--
作者：
Hirsch, JA;Martinez, LM;Sommer, FT
在这里，我们探讨抑制回路在丘脑皮层阶段的处理在第4层的猫的视觉皮层，专注于解剖和生理的中间神经元本身。我们的直接目标是探索有助于方向选择性的抑制机制，这可能是丘脑皮层突触中出现的最引人注目的反应特性。更广泛的目标是了解抑制回路如何运作。使用猫在体的全细胞记录，我们发现，第4层包含两个群体的抑制细胞定义的感受野类简单和复杂。简单细胞对刺激方向有选择性，而复杂细胞则没有。我们的观察有助于解释神经元如何对刺激方向变得敏感，并在刺激对比度变化时保持这种选择性。总的来说，这项工作表明，不同的抑制来源，无论是选择性的特定功能或广泛调整，相互作用，以提供适当的表示环境中的元素。
Here we explore inhibitory circuits at the thalamocortical stage of processing in layer 4 of the cat's visual cortex, focusing on the anatomy and physiology of the interneurons themselves. Our immediate aim was to explore the inhibitory mechanisms that contribute to orientation selectivity, perhaps the most dramatic response property to emerge across the thalamocortical synapse. The broader goal was to understand how inhibitory circuits operate. Using whole-cell recording in cats in vivo, we found that layer 4 contains two populations of inhibitory cells defined by receptive field class-simple and complex. The simple cells were selective for stimulus orientation, whereas the complex cells were not. Our observations help to explain how neurons become sensitive to stimulus orientation and maintain that selectivity as stimulus contrast changes. Overall, the work suggests that different sources of inhibition, either selective for specific features or broadly tuned, interact to provide appropriate representations of elements within the environment.