Mycobacterium bovis BCG vaccination induces memory CD4+ T cells characterized by effector biomarker expression and anti-mycobacterial activity
Mycobacterium bovis BCG vaccination induces memory CD4+ T cells characterized by effector biomarker expression and anti-mycobacterial activity
复制标题
DOI：
10.1016/j.vaccine.2007.10.011
复制
发表时间：
2007-12-05
期刊：
影响因子：
5.5
通讯作者：
Villarreal-Ramos, Bernardo
中科院分区：
文献类型：
--
作者：
Endsley, Janice J.;Hogg, Alison;Villarreal-Ramos, Bernardo
CD 4（+）T细胞用于控制分支杆菌的效应机制在人类和啮齿动物结核病模型之间存在差异，应在其他动物模型中进行研究。在这些研究中，牛模型被用于表征通过接种减毒牛分枝杆菌卡介苗（BCG）诱导的杀分枝杆菌CD 4（+）T细胞应答。BCG免疫牛外周血CD 4（+）T细胞的抗原刺激增强了表达CD 45 RA（-）CD 45 RO（+）CD 62 L（+）细胞表面表型的细胞中穿孔素和IFN γ的表达，增强了颗粒溶素、IFN γ、穿孔素、IL-4、IL-13和IL-21的转录，增强了CD 4（+）T细胞对BCG感染的巨噬细胞的抗分枝杆菌活性。(c)2007爱思唯尔有限公司保留所有权利。
The effector mechanisms used by CD4(+) T cells to control mycobacteria differ between humans and rodent models of TB and should be investigated in additional animal models. In these studies, the bovine model was used to characterize the mycobactericidal CD4(+) T cell response induced by vaccination with the attenuated Mycobacterium bovis bacillus Calmette-Guerin (BCG). Antigenic stimulation of peripheral blood CD4(+) T cells from BCG-vaccinated cattle enhanced expression of perforin and IFN gamma in cells expressing a CD45RA(-)CD45RO(+)CD62L(+) cell surface phenotype, enhanced transcription of granulysin, IFN gamma, perforin, IL-4, IL-13, and IL-21, and enhanced anti-mycobacterial activity of CD4(+) T cells against BCG-infected macrophages. (c) 2007 Elsevier Ltd. All rights reserved.