Effects of sleep disturbances during pregnancy on cardiac autonomic modulation in the resting state
Effects of sleep disturbances during pregnancy on cardiac autonomic modulation in the resting state
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DOI：
10.1016/j.ijgo.2012.05.034
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发表时间：
2012-11-01
影响因子：
3.8
通讯作者：
Kodama, Hideya
中科院分区：
文献类型：
--
作者：
Shiga, Kuniko;Murata, Katsuyuki;Kodama, Hideya
目的：探讨妊娠期睡眠障碍对静息状态下心脏自主神经调节的影响。方法：对160例不同孕期孕妇进行横断面研究。在过去的几周里，参与者接受了关于他们每晚的睡眠时间、睡眠质量(匹兹堡睡眠质量指数，PSQI)、白天嗜睡(爱普沃斯嗜睡量表，ESS)、打鼾习惯和不宁腿综合征症状的采访。通过对短期心电监测心率变异性(HRV)的频谱分析，量化静息状态下的心脏自主神经调节。用多元回归分析研究心率变异性与不同协变量的关系。结果：睡眠时间短(5例)或不宁腿综合征对HRV指标无显著影响。白天过度嗜睡的参与者(ESS评分9分)和习惯性打鼾者的低频/高频(LF/HF)比率和以标准化单位计算的低频功率(如果正常)显著增加。在多元回归分析中，习惯性鼾声与低频/高频比值呈显著正相关(P
Objective: To investigate whether sleep disturbances during pregnancy affect cardiac autonomic modulation in the resting state. Methods: A cross-sectional study was conducted of 160 pregnant women at various stages of gestation. Participants were interviewed about their sleep length per night, sleep quality (Pittsburgh Sleep Quality Index, PSQI), daytime sleepiness (Epworth Sleepiness Scale, ESS), snoring habits, and symptoms of restless legs syndrome during the previous few weeks. Cardiac autonomic modulation in the resting state was quantified by spectral analysis of heart rate variability (HRV) from short-term electrocardiogram monitoring. The relationship of HRV to diverse covariates was studied by multiple regression analysis. Results: No significant influences were observed of short sleep duration (5), or restless legs syndrome on HRV measures. Participants with excessive daytime sleepiness (ESS score >9) and habitual snorers had a significantly elevated low frequency/high frequency (LF/HF) ratio and LF power in normalized units (IF norm). In multiple regression analyses, habitual snoring was strongly and positively associated with LF/HF ratio (P