Calcium microdomains: Organization and function
Calcium microdomains: Organization and function
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DOI：
10.1016/j.ceca.2006.09.002
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发表时间：
2006-11-01
期刊：
影响因子：
4
通讯作者：
Berridge, Michael J.
中科院分区：
文献类型：
--
作者：
Berridge, Michael J.
Ca~(2+)微区是Ca~(2+)信号转导的关键元件，它形成于Ca~(2+)进入细胞质的细胞表面或胞内储存区。术语微域包括作为钙信号的基本构件的基本事件。当钙离子进入细胞质时，它会产生局部的钙离子羽流，并被赋予不同的名称(火花、泡芙、小火花和突触)。这些基本事件可以结合在一起产生更大的微域。这些钙离子局部结构域的意义在于，它们可以调节细胞不同区域的特定细胞过程。这种微域在神经元中尤其明显，突触前和突触后的事件都由高度局部化的钙离子脉冲控制。单个神经元处理大量信息的能力取决于钙离子信号系统的这种微型化。心肌细胞收缩和基因转录的控制提供了另一个例子，说明钙信号的并行处理如何通过细胞内钙离子的微域发生。(C)2006爱思唯尔有限公司。保留所有权利。
Microdomains of Ca2+, which are formed at sites where Ca2+ enters the cytoplasm either at the cell surface or at the internal stores, are a key element of Ca2+ signalling. The term microdomain includes the elementary events that are the basic building blocks of Ca2+ signals. As Ca2+ enters the cytoplasm, it produces a local plume of Ca2+ that has been given different names (sparks, puffs, sparklets and syntillas). These elementary events can combine to produce larger microdomains. The significance of these localized domains of Ca2+ is that they can regulate specific cellular processes in different regions of the cell. Such microdomains are particularly evident in neurons where both pre- and postsynaptic events are controlled by highly localized pulses of Ca2+. The ability of single neurons to process enormous amounts of information depends upon such miniaturization of the Ca2+ signalling system. Control of cardiac cell contraction and gene transcription provides another example of how the parallel processing of Ca2+ signalling can occur through microdomains of intracellular Ca2+. (c) 2006 Elsevier Ltd. All rights reserved.