Activator protein-1 in epiretinal membranes of patients with proliferative diabetic retinopathy
Activator protein-1 in epiretinal membranes of patients with proliferative diabetic retinopathy
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DOI：
10.1007/s00125-005-0059-5
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发表时间：
2005
期刊：
影响因子：
8.2
通讯作者：
Y. Mitamura;A. Okumura;C. Harada;K. Namekata;K. Nakamura;A. Tashimo;K. Ohtsuka;T. Harada
中科院分区：
文献类型：
--
作者：
Y. Mitamura;A. Okumura;C. Harada;K. Namekata;K. Nakamura;A. Tashimo;K. Ohtsuka;T. Harada
To the Editor: Angiogenesis is the most important event in proliferative diabetic retinopathy. Previous studies indicated that activator protein-1 (AP-1) is involved in angiogenesis [1, 2]. AP-1 is a transcription factor and a homodimer or heterodimer mainly composed of Jun-Jun and Jun-Fos. The gene encoding Jun was originally identified in avian sarcoma virus 17, and the abbreviation ‘Jun’is derived from the Japanese ‘ju-nana’, which means 17. c-Jun (encoded by JUN) is a member of the Jun family and is a principal component of AP-1. The aim of the present study was to assess the potential role of AP-1 in the pathogenesis of proliferative diabetic retinopathy. For this purpose, we examined the expression of JUN mRNA in epiretinal membranes secondary to proliferative diabetic retinopathy. Because perivascular glial cells are essential for the regulation of retinal angiogenesis [3], we also examined levels of phosphorylated c-Jun in glial cells from epiretinal membranes.
