Gene conversions and their relation to homologous chromosome pairing.
Gene conversions and their relation to homologous chromosome pairing.
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基因转换及其与同源染色体配对的关系。
DOI：
10.1098/rstb.1986.0008
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
Powers,PA
中科院分区：
文献类型：
--
作者：
Smithies,O;Powers,PA
基因转换是指DNA序列从一个基因到基因组中其他相关基因的非互惠转移。我们的实验室于1980年首次描述了它在高等真核生物中存在的分子证据，发现了两个相连的人类胎儿γ-珠蛋白基因。在这个最初的例子中，超过一千个碱基的DNA被转化。自那以后，其他研究人员描述了更多的基因转换例子，包括一些被转移的序列要短得多的例子。我们现在已经积累了人类胎儿珠蛋白基因对中一系列如此小的基因转换的证据。我们能够检测到的小基因转换的数量使我们认为，基因转换是一种一般机制的结果，在减数分裂过程中，DNA链入侵使染色体能够找到它们的同源物。
Gene conversion is the non-reciprocal transfer of DNA sequences from one gene to a related gene elsewhere in the genome. Molecular evidence for its occurrence in higher eukaryotes was first described by our laboratory in 1980 in the two linked human foetal y-globin genes. Over a kilobase of DNA was converted in this initial example. Other investigators have since described more examples of gene conversion including some in which the sequence that was transferred is much shorter. We have now accumulated evidence for a series of such small gene conversions in the human foetal globin gene pair. The number of small gene conversions that we have been able to detect leads us to suggest that gene conversions are the consequence of a general mechanism whereby DNA strand invasions enable chromosomes to find their homologues during meiosis.