Nongenomic androgen activation of phosphatidylinositol 3-kinase/Akt signaling pathway in MC3T3-E1 osteoblasts
Nongenomic androgen activation of phosphatidylinositol 3-kinase/Akt signaling pathway in MC3T3-E1 osteoblasts
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DOI：
10.1359/jbmr.040306
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发表时间：
2004-07-01
影响因子：
6.2
通讯作者：
Huang, KE
中科院分区：
文献类型：
--
作者：
Kang, HY;Cho, CL;Huang, KE
雄激素对骨代谢有重要影响。然而，雄激素对成骨细胞的作用及其机制尚不清楚。在这里，我们发现雄激素增加Akt的磷酸化和核转位。siRNA-AR阻止雄激素诱导的MC 3 T3-E1细胞中Akt活化。这表明Akt的非基因组雄激素激活是由成骨细胞中的雄激素受体介导的。
Androgens have important effects on the bone metabolism. However, the effect and mechanism of androgen action on the osteoblasts remains unknown. Here we showed that androgens increase phosphorylation and nuclear translocation of Akt. siRNA-AR prevented androgen-induced Akt activation in MC3T3-E1 cells. This suggests that nongenomic androgen activation of Akt is mediated by androgen receptor in osteoblasts.