Pioglitazone attenuates atrial remodeling and vulnerability to atrial fibrillation in alloxan-induced diabetic rabbits
Pioglitazone attenuates atrial remodeling and vulnerability to atrial fibrillation in alloxan-induced diabetic rabbits
复制标题
吡格列酮可减轻四氧嘧啶诱发的糖尿病兔的心房重塑和房颤易感性
DOI：
10.1111/1755-5922.12284
复制
发表时间：
2017-10-01
影响因子：
3.1
通讯作者：
Liu, Tong
中科院分区：
文献类型：
--
作者：
Liu, Changle;Liu, Ruimeng;Liu, Tong
背景/目的最近的证据表明，过氧化物酶体增殖物激活受体(PPAR)激活剂具有抗炎和抗氧化作用。然而，这些药物阻止糖尿病患者心房重构的潜在机制尚未完全阐明。目的探讨PPAR激动剂吡格列酮对糖尿病兔心房重构和房颤诱发率的影响。方法将糖尿病兔随机分为3组：单纯糖尿病组、糖尿病小剂量组(4 mg/d/kg)、糖尿病大剂量组(8 mg/d/kg)(n=24)。健康兔24只作为对照组。8周后记录血流动力学、超声心动图和电生理参数。结果DM组与DM组比较，差异有统计学意义(6/8vs1/8，P
Background/AimsRecent evidence indicates that peroxisome proliferator-activated receptor (PPAR)- activators exert anti-inflammatory and antioxidant actions. However, the underlying mechanisms by which these agents prevent atrial remodeling in diabetes are not completely elucidated. We sought to investigate the potential effects of pioglitazone, a PPAR- activator, on atrial remodeling and atrial fibrillation (AF) inducibility in diabetic rabbits.MethodsAlloxan-induced diabetic rabbits were randomly divided into three groups: diabetes only, diabetes treated with low-dose pioglitazone (4mg/day/kg), or diabetes treated with high-dose pioglitazone (8mg/day/kg) (n=24 for each group). A total of 24 healthy rabbits served as controls. Eight weeks later, hemodynamic, echocardiographic, and electrophysiological parameters were recorded. Left atrial whole-cell patch-clamp studies, histological examination, and Western blot analysis were also performed.ResultsIn the DM group (6/8 vs 1/8, P