The Estimated Lifetime Quality-Adjusted Life-Years Lost Due to Chlamydia, Gonorrhea, and Trichomoniasis in the United States in 2018.
The Estimated Lifetime Quality-Adjusted Life-Years Lost Due to Chlamydia, Gonorrhea, and Trichomoniasis in the United States in 2018.
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DOI：
10.1093/infdis/jiad047
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发表时间：
2023-04-18
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--
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在美国，缺乏对衣原体、淋病和滴虫病造成的质量调整寿命年(QALY)损失的全面评估。我们采用了先前的概率树模型，根据性别和年龄组，在人群水平上，根据每个事件的感染，估计了因生殖器衣原体、淋病和滴虫病而损失的终身QALY的平均数量。我们进行了多变量敏感性分析，以解决关键参数值的不确定性。在2018年，男性和女性因感染而损失的总折扣终生QALY分别为衣原体1541(95%不确定区间，186-6358)和111 872(95%UI，29 777-267 404)，淋病989(95%UI，127-3720)和12 112(95%UI，2 410-33 895)，滴虫病386(95%UI，30-1851)和4576(95%UI，13-30 355)。在15-24岁衣原体感染的女性中，总的QALY损失最高。QALY损失的估计对感染和后遗症的不实用(健康损失)，以及女性衣原体和淋病的感染持续时间和慢性后遗症高度敏感。这三种性传播感染在美国造成了重大的健康损失，特别是女性中的淋病和衣原体感染。对每次感染损失的终生QALY的估计有助于确定预防政策的优先顺序，并为性传播感染干预措施的成本效益分析提供信息。2018年，衣原体、淋病和滴虫病在美国造成大量终身质量调整寿命年(QALY)的损失，特别是在女性中。对每次感染损失的终生QALY的估计有助于确定预防政策的优先顺序，并为性传播感染干预措施的成本效益分析提供信息。
Comprehensive evaluation of the quality-adjusted life-years (QALYs) lost attributable to chlamydia, gonorrhea, andtrichomoniasis in the United States is lacking. We adapted a previous probability-tree model to estimate the average number of lifetime QALYs lost due to genital chlamydia, gonorrhea, and trichomoniasis, per incident infection and at the population level, by sex and age group. We conducted multivariate sensitivity analyses to address uncertainty around key parameter values. The estimated total discounted lifetime QALYs lost for men and women, respectively, due to infections acquired in 2018, were 1541 (95% uncertainty interval [UI], 186–6358) and 111 872 (95% UI, 29 777–267 404) for chlamydia, 989 (95% UI, 127–3720) and 12 112 (95% UI, 2 410–33 895) for gonorrhea, and 386 (95% UI, 30–1851) and 4576 (95% UI, 13–30 355) for trichomoniasis. Total QALYs lost were highest among women aged 15–24 years with chlamydia. QALYs lost estimates were highly sensitive to disutilities (health losses) of infections and sequelae, and to duration of infections and chronic sequelae for chlamydia and gonorrhea in women. The 3 sexually transmitted infections cause substantial health losses in the United States, particularly gonorrhea and chlamydia among women. The estimates of lifetime QALYs lost per infection help to prioritize prevention policies and inform cost-effectiveness analyses of sexually transmitted infection interventions. Chlamydia, gonorrhea, and trichomoniasis cause substantial lifetime quality-adjusted life-years (QALYs) lost in the United States in 2018, particularly among women. The estimates of lifetime QALYs lost per infection help to prioritize prevention policies and inform cost-effectiveness analyses of STI interventions.
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影响因子：
15.8
作者：
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