THE EFFECT ON MINIMUM TUMOR DOSE OF RESTRICTING TARGET-DOSE INHOMOGENEITY IN OPTIMIZED 3-DIMENSIONAL TREATMENT OF LUNG-CANCER
THE EFFECT ON MINIMUM TUMOR DOSE OF RESTRICTING TARGET-DOSE INHOMOGENEITY IN OPTIMIZED 3-DIMENSIONAL TREATMENT OF LUNG-CANCER
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DOI：
10.1016/0167-8140(91)90049-m
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发表时间：
1991-08-01
影响因子：
5.7
通讯作者：
HA, C
中科院分区：
文献类型：
--
作者：
LANGER, M;KIJEWSKI, P;HA, C
检查了对靶区剂量变化的限制对最小肿瘤剂量的影响。 如果稍微放松所需的靶剂量均匀性水平，则可能出现最小肿瘤剂量的实质性改善。 据证实，这种效果可以通过最佳计划和三维评估的治疗来观察。 用计算机控制的加速器治疗的晚期肺癌模型被用来检验这一假设。 使用优化射束权重的数学程序来确定可能的最大最小肿瘤剂量。 在测试的六个病例中，如果接受20%的不均匀性限制，则可以递送> 80戈伊的最小肿瘤剂量。 当不均匀性限制收紧到13- 17%时，最小肿瘤剂量下降到44-64戈伊的范围。 结果意味着需要检查选择所需的剂量均匀性水平的范围内的值建议在2维规划文献。 如果保持严格的约束剂量均匀性，则可以减少靶剂量不均匀性的机制（例如形式优化）将是有价值的。
An examination was made of the effect upon the minimum tumor dose of a limit placed on the variation of dose across target. If the required level of target dose uniformity is slightly relaxed, a substantial improvement in the minimum tumor dose might appear. It was conjectured that this effect could be seen with treatments optimally planned and evaluated in three-dimensions. A model of advanced carcinoma of the lung treated with a computer controlled accelerator was used to test this hypothesis. A mathematical program for optimizing beam weights was used to determine the largest minimum tumor dose possible. In the six cases tested, a minimum tumor dose of > 80 Gy could be delivered if a 20% inhomogeneity limit was accepted. The minimum tumor dose fell to the range 44-64 Gy when the inhomogeneity limit was tightened to 13-17%. The results imply a need to examine the choice of a required level of dose uniformity from the range of values suggested in the 2-dimensional planning literature. If a strict bound-on-dose uniformity is preserved, mechanisms - such as formal optimization - which can reduce target dose inhomogeneity will be valuable.